2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Spaglumic Acid

Spaglumic Acid  (Synonyms: N-Acetylaspartylglutamic acid)

Cat. No.: HY-100921 Purity: ≥98.0%
COA Handling Instructions

Molarity Calculator

Spaglumic Acid (N-Acetylaspartylglutamic acid) is a neuropeptide found in millimolar concentrations in brain.

For research use only. We do not sell to patients.

Spaglumic Acid Chemical Structure

Spaglumic Acid Chemical Structure

CAS No. : 3106-85-2

Size Price Stock Quantity
5 mg USD 32 In-stock
10 mg USD 50 In-stock
50 mg USD 145 In-stock
100 mg USD 225 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Spaglumic Acid Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Spaglumic Acid (N-Acetylaspartylglutamic acid) is a neuropeptide found in millimolar concentrations in brain.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Spaglumic Acid (N-Acetylaspartylglutamate; NAAG) is released upon depolarization by a Ca2+-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. Spaglumic Acid is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of Spaglumic Acid and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Spaglumic Acid Related Antibodies
Molecular Weight

304.25

Formula

C11H16N2O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CC[C@@H](C(O)=O)NC([C@H](CC(O)=O)NC(C)=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (821.69 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2868 mL 16.4339 mL 32.8677 mL
5 mM 0.6574 mL 3.2868 mL 6.5735 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (328.68 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (248 KB) HNMR (218 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.2868 mL 16.4339 mL 32.8677 mL 82.1693 mL
5 mM 0.6574 mL 3.2868 mL 6.5735 mL 16.4339 mL
10 mM 0.3287 mL 1.6434 mL 3.2868 mL 8.2169 mL
15 mM 0.2191 mL 1.0956 mL 2.1912 mL 5.4780 mL
20 mM 0.1643 mL 0.8217 mL 1.6434 mL 4.1085 mL
25 mM 0.1315 mL 0.6574 mL 1.3147 mL 3.2868 mL
30 mM 0.1096 mL 0.5478 mL 1.0956 mL 2.7390 mL
40 mM 0.0822 mL 0.4108 mL 0.8217 mL 2.0542 mL
50 mM 0.0657 mL 0.3287 mL 0.6574 mL 1.6434 mL
60 mM 0.0548 mL 0.2739 mL 0.5478 mL 1.3695 mL
80 mM 0.0411 mL 0.2054 mL 0.4108 mL 1.0271 mL
100 mM 0.0329 mL 0.1643 mL 0.3287 mL 0.8217 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Spaglumic Acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Spaglumic Acid3106-85-2N-Acetylaspartylglutamic acidEndogenous MetaboliteInhibitorinhibitorinhibit

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