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  3. Mangafodipir trisodium

Mangafodipir trisodium  (Synonyms: MnDPDP)

Cat. No.: HY-B0993 Purity: 99.82%
COA Handling Instructions

Mangafodipir trisodium (MnDPDP), hepatocellular-specific contrast agent, is an efficacious inhibitor of CIPN (chemotherapy-induced peripheral neuropath) and other conditions caused by cellular oxidative stress. Mangafodipir trisodium shows no negative interference with the tumoricidal activity of chemotherapy.

For research use only. We do not sell to patients.

Mangafodipir trisodium Chemical Structure

Mangafodipir trisodium Chemical Structure

CAS No. : 140678-14-4

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 362 In-stock
Solution
10 mM * 1 mL in Water USD 362 In-stock
Solid
1 mg USD 108 In-stock
5 mg USD 270 In-stock
10 mg USD 435 In-stock
25 mg USD 870 In-stock
50 mg USD 1390 In-stock
100 mg USD 2200 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Mangafodipir trisodium:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Mangafodipir trisodium (MnDPDP), hepatocellular-specific contrast agent, is an efficacious inhibitor of CIPN (chemotherapy-induced peripheral neuropath) and other conditions caused by cellular oxidative stress. Mangafodipir trisodium shows no negative interference with the tumoricidal activity of chemotherapy[1][2].

In Vitro

Mangafodipir trisodium (40, 200 and 1000 μM) inhibits the effect of HGrC cell viability caused by H2O2[3].
Mangafodipir trisodium (200 and 1000 μM) attenuats the apoptosis caused by cisplatin in HGrC cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mangafodipir trisodium (10 mg/kg; i.p., once) shows protective effects against ovarian damage caused by cisplatin and paclitaxel in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CD-1(ICR) Mice with cisplatin- and paclitaxel-induced ovarian damage[3]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; 10 mg/kg, once
Result: Attenuated the loss of primordial follicles, reduction of secondary follicles and increase of antral follicles. Prevented the change of primary follicles caused by cisplatin and paclitaxel. Reduced the increasing of cleaved caspase-3 levels caused by cisplatin and paclitaxel.
Clinical Trial
Molecular Weight

757.32

Formula

C22H27MnN4Na3O14P2

CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

O=C1[O-][Mn+2]([N]2(C3)CC4=C5COP(O)(O)=O)([O-]C6=C(N=C7)C)([O-]C4=C(N=C5)C)([O-]C3=O)[N](CC6=C7COP([O-])(O)=O)(CC2)C1.[Na+].[Na+].[Na+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (44.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3204 mL 6.6022 mL 13.2045 mL
5 mM 0.2641 mL 1.3204 mL 2.6409 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (132.04 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.82%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3204 mL 6.6022 mL 13.2045 mL 33.0111 mL
5 mM 0.2641 mL 1.3204 mL 2.6409 mL 6.6022 mL
10 mM 0.1320 mL 0.6602 mL 1.3204 mL 3.3011 mL
15 mM 0.0880 mL 0.4401 mL 0.8803 mL 2.2007 mL
20 mM 0.0660 mL 0.3301 mL 0.6602 mL 1.6506 mL
25 mM 0.0528 mL 0.2641 mL 0.5282 mL 1.3204 mL
30 mM 0.0440 mL 0.2201 mL 0.4401 mL 1.1004 mL
40 mM 0.0330 mL 0.1651 mL 0.3301 mL 0.8253 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mangafodipir trisodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Mangafodipir trisodium
Cat. No.:
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