2. Netarsudil hydrochloride

Netarsudil hydrochloride  (Synonyms: AR-13324 hydrochloride)

Cat. No.: HY-12798B Purity: 99.77%
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Netarsudil hydrochloride (AR-13324 hydrochloride) is a Rho-associated protein kinas (ROCK) and norepinephrine transporter (NET) inhibitor. Netarsudil hydrochloride has effective in intraocular pressure (IOP) reduction.

For research use only. We do not sell to patients.

Netarsudil hydrochloride Chemical Structure

Netarsudil hydrochloride Chemical Structure

CAS No. : 1253952-02-1

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Netarsudil hydrochloride Related Antibodies

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Description

Netarsudil hydrochloride (AR-13324 hydrochloride) is a Rho-associated protein kinas (ROCK) and norepinephrine transporter (NET) inhibitor. Netarsudil hydrochloride has effective in intraocular pressure (IOP) reduction[1][2].

IC50 & Target

ROCK, NET[1][2]
In Vivo

Netarsudil hydrochloride (0.04%, 50 ΜL)reduces intraocular pressure (IOP) in normotensive monkey eyes[1].
Netarsudil hydrochloride (0.04%) produces statistically significant lowering of episcleral venous pressure (EVP) in Dutch Belted rabbits[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult female cynomolgus monkeys (3-5 kg)[1]
Dosage: 0.04%, 50 μL
Administration: Topically applied to eye
Result: Reduces IOP in normotensive monkey eyes.
Molecular Weight

526.45

Formula

C28H29Cl2N3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CC(C)=C(C(OCC2=CC=C([C@@H](CN)C(NC3=CC(C=CN=C4)=C4C=C3)=O)C=C2)=O)C=C1.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (9.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8995 mL 9.4976 mL 18.9952 mL
5 mM 0.3799 mL 1.8995 mL 3.7990 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.77%

COA (246 KB) HNMR (274 KB) RP-HPLC (201 KB) MS (69 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8995 mL 9.4976 mL 18.9952 mL 47.4879 mL
5 mM 0.3799 mL 1.8995 mL 3.7990 mL 9.4976 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Netarsudil1253952-02-1AR-13324AR13324AR 13324Inhibitorinhibitorinhibit

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