1. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  2. Adrenergic Receptor Endogenous Metabolite
  3. Octopamine hydrochloride

Octopamine hydrochloride  (Synonyms: (±)-p-Octopamine hydrochloride)

Cat. No.: HY-B0528A Purity: 99.65%
COA Handling Instructions

Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure.

For research use only. We do not sell to patients.

Octopamine hydrochloride Chemical Structure

Octopamine hydrochloride Chemical Structure

CAS No. : 770-05-8

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Solid
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1 g USD 66 In-stock
5 g USD 99 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Octopamine hydrochloride:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Octopamine hydrochloride

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure[1][2][3].

IC50 & Target[1][2]

Human Endogenous Metabolite

 

α2-adrenergic receptor

 

In Vitro

Octopamine has a prominent role in influencing multiple physiological events: (a) as a neuromodulator, it regulates desensitization of sensory inputs, arousal, initiation, and maintenance of various rhythmic behaviors and complex behaviors such as learning and memory; (b) as a neurotransmitter, it regulates endocrine gland activity; and (c) as a neurohormone, it induces mobilization of lipids and carbohydrates. Octopamine exerts its effects by binding to specific proteins that belong to the superfamily of G protein-coupled receptors and share the structural motif of seven transmembrane domains[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

189.64

Formula

C8H12ClNO2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C1=CC=C(O)C=C1)CN.Cl

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (527.31 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 50 mg/mL (263.66 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2731 mL 26.3657 mL 52.7315 mL
5 mM 1.0546 mL 5.2731 mL 10.5463 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (527.31 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 5.2731 mL 26.3657 mL 52.7315 mL 131.8287 mL
5 mM 1.0546 mL 5.2731 mL 10.5463 mL 26.3657 mL
10 mM 0.5273 mL 2.6366 mL 5.2731 mL 13.1829 mL
15 mM 0.3515 mL 1.7577 mL 3.5154 mL 8.7886 mL
20 mM 0.2637 mL 1.3183 mL 2.6366 mL 6.5914 mL
25 mM 0.2109 mL 1.0546 mL 2.1093 mL 5.2731 mL
30 mM 0.1758 mL 0.8789 mL 1.7577 mL 4.3943 mL
40 mM 0.1318 mL 0.6591 mL 1.3183 mL 3.2957 mL
50 mM 0.1055 mL 0.5273 mL 1.0546 mL 2.6366 mL
60 mM 0.0879 mL 0.4394 mL 0.8789 mL 2.1971 mL
80 mM 0.0659 mL 0.3296 mL 0.6591 mL 1.6479 mL
100 mM 0.0527 mL 0.2637 mL 0.5273 mL 1.3183 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Octopamine hydrochloride
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HY-B0528A
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