1. SRI-011381 hydrochloride

SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects.

For research use only. We do not sell to patients.

SRI-011381 hydrochloride Chemical Structure

SRI-011381 hydrochloride Chemical Structure

CAS No. : 2070014-88-7

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 88 In-stock
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10 mM * 1 mL in DMSO USD 88 In-stock
Solid
5 mg USD 80 In-stock
10 mg USD 140 In-stock
25 mg USD 290 In-stock
50 mg USD 480 In-stock
100 mg USD 790 In-stock
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Customer Review

Based on 30 publication(s) in Google Scholar

Other Forms of SRI-011381 hydrochloride:

Top Publications Citing Use of Products

28 Publications Citing Use of MCE SRI-011381 hydrochloride

WB

    SRI-011381 hydrochloride purchased from MedChemExpress. Usage Cited in: Life Sci. 2021 Aug 15;279:119359.  [Abstract]

    The expression of pSmad2/3 in PBMCs treated with Curcumin or SRI-011381 (10 μM) detected by Western blot analysis normalized to GAPDH. SRI-011381 is found to up-regulate the phosphorylation of Smad2/3, while Curcumin reduces the activation of Smad2/3, whereas the inhibitory effect of curcumin in the activation of Smad2/3 is reversed by SRI-011381.

    SRI-011381 hydrochloride purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2021 Nov;24(5):758.  [Abstract]

    Mimics-exo significantly inhibits the expression levels of TGF-β2 and p-Smad3, as well as downregulated the expression levels of Col-I, Col-III and α-SMA, while SRI-011381 hydrochloride (10 µM) reverses the inhibition of miR-29a-overexpressing hADSCs-exo on the activation of TGF-β2/Smad3 signaling and the fibrosis of HSFBs.
    • Biological Activity

    • Purity & Documentation

    • Customer Review

    Description

    SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2].

    IC50 & Target

    TGF-beta[1]

    In Vitro

    SRI-011381 (10 μM) hydrochloride promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3, collagen-1, and α-SMA expression[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) hydrochloride partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)[2]
    Dosage: 30 mg/kg
    Administration: Intraperitoneally injection; every 2 d; for 22 days
    Result: Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice.
    Molecular Weight

    365.94

    Formula

    C20H32ClN3O

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(NC1CCCCC1)N(CC2=CC=CC=C2)CC3CCNCC3.Cl[H]

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 33.33 mg/mL (91.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 25 mg/mL (68.32 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7327 mL 13.6634 mL 27.3269 mL
    5 mM 0.5465 mL 2.7327 mL 5.4654 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (6.83 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (6.83 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (136.63 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 2.7327 mL 13.6634 mL 27.3269 mL 68.3172 mL
    5 mM 0.5465 mL 2.7327 mL 5.4654 mL 13.6634 mL
    10 mM 0.2733 mL 1.3663 mL 2.7327 mL 6.8317 mL
    15 mM 0.1822 mL 0.9109 mL 1.8218 mL 4.5545 mL
    20 mM 0.1366 mL 0.6832 mL 1.3663 mL 3.4159 mL
    25 mM 0.1093 mL 0.5465 mL 1.0931 mL 2.7327 mL
    30 mM 0.0911 mL 0.4554 mL 0.9109 mL 2.2772 mL
    40 mM 0.0683 mL 0.3416 mL 0.6832 mL 1.7079 mL
    50 mM 0.0547 mL 0.2733 mL 0.5465 mL 1.3663 mL
    60 mM 0.0455 mL 0.2277 mL 0.4554 mL 1.1386 mL
    DMSO 80 mM 0.0342 mL 0.1708 mL 0.3416 mL 0.8540 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    SRI-011381 hydrochloride
    Cat. No.:
    HY-100347A
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