Sodium formononetin-3'-sulfonate (Synonyms: Sul-F)

Cat. No.: HY-13063 Purity: 99.79%: FAQs
Data Sheet SDS COA Handling Instructions

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Sodium formononetin-3'-sulfonate (Sul-F) is a water-sol.

For research use only. We do not sell to patients.

Sodium formononetin-3'-sulfonate Chemical Structure

CAS No. : 949021-68-5

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 275	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 275	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 460	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Purity & Documentation
References
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Description

Sodium formononetin-3'-sulfonate (Sul-F) is a water-sol. derivate of formononetin. IC50 value: Target: Research results showed that treatment with Sul-F significantly prevented the elevation of ST-segment level, decreased the contents of creatine kinase-MB, lactate dehydrogenase, alanine aminotransferase and cardiac troponin T in serum and reduced the myocardium necrosis scores. These findings indicate that Sul-F has a protective potential against myocardial infarction injury. A possible mechanism for the protective effect is the elevated expression of endogenous antioxidant defense enzymes degraded lipid peroxidn. products and improved energy metab. of cardiac mitochondrial, thus attenuating cardiocyte apoptosis. Other reaearch results showed that sodium formononetin-3'-sulfonate not only had favorable water, solubility but also had good lipid-lowering and liver-protection activities.

Molecular Weight

370.31

Formula

C₁₆H₁₁NaO₇S

CAS No.

949021-68-5

Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=C(C2=C1)C(C(C3=CC(S(=O)(O[Na])=O)=C(OC)C=C3)=CO2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (270.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 25 mg/mL (67.51 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7004 mL	13.5022 mL	27.0044 mL
5 mM	0.5401 mL	2.7004 mL	5.4009 mL
10 mM	0.2700 mL	1.3502 mL	2.7004 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.79%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (249 KB) LCMS (267 KB)

Handling Instructions (2659 KB)

References

[1]. Zhang, Shumin; Tang, Xuexi; Tian, Jingwei et al. Cardioprotective effect of sulphonated formononetin on acute myocardial infarction in rats. Basic & Clinical Pharmacology & Toxicology (2011), 108(6), 390-395. [Content Brief]

[2]. Wang, Qiuya; Meng, Qinghua; Zhang, Zunting et al. Synthesis, solubility, lipids-lowering and liver-protection activities of sulfonated formononetin. Yaoxue Xuebao (2009), 44(4), 386-389. [Content Brief]

[3]. Cardioprotective Effect of Sulfonated Formononetin on Acute Myocardial Infarction in Rats.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.7004 mL	13.5022 mL	27.0044 mL	67.5110 mL
	5 mM	0.5401 mL	2.7004 mL	5.4009 mL	13.5022 mL
	10 mM	0.2700 mL	1.3502 mL	2.7004 mL	6.7511 mL
	15 mM	0.1800 mL	0.9001 mL	1.8003 mL	4.5007 mL
	20 mM	0.1350 mL	0.6751 mL	1.3502 mL	3.3756 mL
	25 mM	0.1080 mL	0.5401 mL	1.0802 mL	2.7004 mL
	30 mM	0.0900 mL	0.4501 mL	0.9001 mL	2.2504 mL
	40 mM	0.0675 mL	0.3376 mL	0.6751 mL	1.6878 mL
	50 mM	0.0540 mL	0.2700 mL	0.5401 mL	1.3502 mL
	60 mM	0.0450 mL	0.2250 mL	0.4501 mL	1.1252 mL
DMSO	80 mM	0.0338 mL	0.1688 mL	0.3376 mL	0.8439 mL
DMSO	100 mM	0.0270 mL	0.1350 mL	0.2700 mL	0.6751 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Sodium formononetin-3'-sulfonate Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sodium formononetin-3'-sulfonate949021-68-5Sul-FReactive Oxygen SpeciesInhibitorinhibitorinhibit

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