CaMK

Calmodulin-dependent protein kinases; Calmodulin-dependent kinases

CaMK

Related Products

The Ca²⁺/calmodulin-dependent kinase (CaMK) family has been recognized as a key mediator in living organisms and various biological processes.

CaMK II is a multifunctional cytoplasmic calcium and calmodulin-dependent protein kinase that phosphorylates and alters the function of a variety of substrates. The CaMK II pathway has been found to regulate the RANKL-induced osteoclast formation via the cAMP-response element binding protein (CREB) pathway.

Among many signaling pathways of proliferation, intracellular calciumol/L has been extensively demonstrated to be very important. In cytoplasm, calciumol/L binds to calmodulin, and then activates the CaMKs which are a family of structurally related serine/threonine protein kinases including CaMKI-IV. CaMKII, a multi functional protein kinase, is ubiquitously involved in many physiological processes including control of cell cycle, apoptosis, gene expression, and neurotransmission.

CaMK Related Products (42)
Antibodies (3)

By Effects:	Inhibitors (27) Degrader (1) Antagonist (1) Activator (1) Modulator (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P0271A

Syntide 2 TFA		99.26%
Syntide 2 (TFA), a Ca²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected.

HY-P1479A

Calmodulin-Dependent Protein Kinase II(290-309) acetate		98.45%
Calmodulin-Dependent Protein Kinase II (290-309) acetate is a potent CaMK antagonist with an IC₅₀ of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.

HY-126396

Sordarin sodium	Inhibitor	≥99.0%
Sordarin is a potent diphthamide-dependent eEF2 inhibitor with antifungal properties. Sordarin targets eEF2 so as to inhibit protein translation by blocking eEF2-mediated translocation of tRNAs. Sordarin inhibits translation specifically in certain fungi (e.g. C. albicans, C. glabrata, and C. neoformans) while unable to do so in some other fungal species (e.g. Candida parapsilosis and Candida lusitaniae).

HY-W013857

Lavendustin C	Inhibitor	98.32%
Lavendustin C is a potent Ca²⁺ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC₅₀ of 0.2 µM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC₅₀=0.012 µM) and pp60^c-src(+) kinase (IC₅₀=0.5 µM) .

HY-125957

A-3 hydrochloride	Inhibitor	99.75%
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (K_i=4.3 µM), casein kinase II (K_i=5.1 µM) and myosin light chain kinase (MLCK) (K_i=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with K_i values of 47 µM and 80 µM, respectively.

HY-P3811A

Autocamtide-3 acetate		99.62%
Autocamtide-3 acetate, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca²⁺/calmodulin-dependent kinase II) (CaMK) substrate.

HY-P0271

Syntide 2
Syntide 2, a Ca²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected.

HY-P1528

Autocamtide 2, amide		99.50%
Autocamtide 2, amide is a substrate (100 μM final concentration) for CaMK family assays.

HY-146268

CaMKIIα-IN-1	Inhibitor	98.41%
CaMKIIα-IN-1 (Compound 4d) is an orally active Ca²⁺/calmodulin-dependent protein kinase II α (CaMKIIα) inhibitor with a K_D of 219 nM for CaMKIIα WT hub. CaMKIIα-IN-1 has good metabolic stability.

HY-151797

Ph-HTBA	Modulator
Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a K_d value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders.

HY-P0214

Autocamtide-2-related inhibitory peptide	Inhibitor
Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM.

HY-P3944

Calmodulin Dependent Protein Kinase Substrate
Calmodulin Dependent Protein Kinase Substrate is a Ca²⁺- and calmodulin (CaM)-dependent protein kinase (CaMK) substrate peptide. Calmodulin Dependent Protein Kinase Substrate is a synthetic peptide substrate for protein kinases.

HY-P0215A

Autocamtide-2-related inhibitory peptide, myristoylated TFA	Inhibitor
Autocamtide-2-related inhibitory peptide, myristoylated TFA is the myristoylated Autocamtide-2-related inhibitory peptide. Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM.

HY-121828

TX-1123	Inhibitor
TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC₅₀ values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer.

HY-P1479

Calmodulin-Dependent Protein Kinase II (290-309)
Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC₅₀ of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.

HY-P3811

Autocamtide-3
Autocamtide-3, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca²⁺/calmodulin-dependent kinase II) (CaMK) substrate.

HY-15720B

Glycyl H-1152 hydrochloride	Inhibitor
Glycyl H-1152 hydrochloride (compound 18) is a glycyl derivative of Rho-kinase inhibitors H-1152 dihydrochloride. Glycyl H-1152 hydrochloride inhibits ROCKII, Aurora A, CAMKII and PKG, with IC₅₀s of 0.0118, 2.35, 2.57 and 3.26 μM respectively. Glycyl H-1152 hydrochloride has higher selective than H-1152 hydrochloride.

HY-P5525

AC3-I, myristoylated	Inhibitor
AC3-I, myristoylated is a biological active peptide. (This is a myristoylated form of Autocamtide-3-Derived Inhibitory Peptide (AC3-I), a highly specific inhibitor of Calmodulin-Dependent Protein Kinase ll (CaMKII) that is resistant to proteolysis. AC3-I is derived from Autocamtide-3, a substrate for CaMKII, with the Thr-9 phosphorylation site substituted with Ala.)

HY-146324

PROTAC eEF2K degrader-1	Inhibitor
PROTAC eEF2K degrader-1 (Compound 11l) is an eEF2K-Targeting PROTAC small molecule that induces apoptosis in MDA-MB-231 cells. PROTAC eEF2K degrader-1 mediates eEF2K degradation.

HY-P3943

Calmodulin Dependent Protein Kinase Substrate Analog
Calmodulin Dependent Protein Kinase Substrate Analog is a Ca²⁺- and calmodulin (CaM)-dependent protein kinase (CaMK) substrate peptide. Calmodulin Dependent Protein Kinase Substrate Analog is a synthetic peptide substrate for protein kinases.

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CaMK

CaMK

CaMK Related Products (42)

Antibodies (3)

CaMK Related Products (42):