2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Elastase

Elastase

Elastase

Related Products

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Elastase is a group of serine proteases that include the macrophage elastase, the fibroblast elastase, the neutrophil elastase, and the pancreatic elastase. Elastase can not only cleave the important connective tissue protein elastin, but also facilitate the degradation of the extracellular matrix such as fibronectin; laminin; collagens III, IV, and VI; and proteoglycans.

Mammalian elastases occur mainly in the pancreas and the phagocytes. Among non-mammalian elastases there is a great variety of bacterial metallo and serine elastases. The elastolytic activity varies from one elastase to another and is usually not correlated with the catalytic efficiency of these proteinases. There is a large number of natural (proteins) and synthetic elastase inhibitors. Elastases play a pathologic role in pulmonary emphysema, cystic fibrosis, infections, inflammation, and atherosclerosis.

Elastase Related Products (47):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-100240
    Lodelaben
    		Inhibitor
    Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 μM, respectively.
    Lodelaben
  • HY-N8164
    19α-Hydroxyasiatic acid
    		Inhibitor 99.56%
    19α-Hydroxyasiatic acid, a natural triterpenoid, possesses anti-elastase activity.
    19α-Hydroxyasiatic acid
  • HY-15652
    Freselestat
    		Inhibitor 99.00%
    Freselestat (ONO-6818) is a potent and orally active neutrophil elastase inhibitor with a Ki of 12.2 nM. Freselestat is >100-fold less-active against other proteases such as trypsin, protein-ase 3, pancreatic elastase, plasmin, thrombin, collagenase, cathepsin G, and murine macrophage elastase. Freselestat has a potent anti-inflammatory activity.
    Freselestat
  • HY-U00256
    ZD8321
    		Inhibitor
    ZD8321 is a potent inhibitor of human Neutrophil elastase (NE) with a Ki of 13±1.7 nM.
    ZD8321
  • HY-P4669
    KLK7/ELA2-IN-1
    		Inhibitor
    KLK7/ELA2-IN-1 is a potent kallikrein-related peptidase 7 (KLK7) and epidermal elastase 2 (ELA2) inhibitor with IC50s of 6 nM and 55 nM, respectively (WO2009024527A1, Example 4).
    KLK7/ELA2-IN-1
  • HY-15651A
    Alvelestat tosylate
    		Inhibitor
    Alvelestat (tosylate) is an orally bioavailable, affinity and selective inhibitor of neutrophil elastase (NE) with a pIC50 value of 7.9 nM, a Ki value of 9.4 nM and a Kd value of 9.5 nM.
    Alvelestat tosylate
  • HY-P4346
    MeOSuc-Ala-Ala-Pro-Met-AMC
    MeOSuc-Ala-Ala-Pro-Met-AMC is a peptide substrate of elastases and chymotrypsin-like serine peptidases.
    MeOSuc-Ala-Ala-Pro-Met-AMC
  • HY-P5459
    Elafin(human)
    		Inhibitor
    Elafin,also known as elafin-specific inhibitor (ESI) or skin anti-leucoprotease (SKALP), is a low molecular weight inhibitor of human neutrophil elastase (HNE) and proteinase 3 in lung. Elafin is antibiotic against Pseudomonas aeruginosa and Staphylococcus aureus.
    Elafin(human)
  • HY-P3648
    Ala-Ala-Pro-Val-chloromethylketone
    		Inhibitor
    Ala-Ala-Pro-Val-chloromethylketone is an irreversible human neutrophil elastase (NE) inhibitor for use in the study of chronic inflammatory airway diseases.
    Ala-Ala-Pro-Val-chloromethylketone
  • HY-130294
    Pyracrenic acid
    		Inhibitor
    Pyracrenic acid is an elastase inhibitor (IC50 = 2.42 µM), can be obtained from the bark of Pyracantha crenulata. Pyracrenic acid has DPPH free radical scavenging activity and anti-inflammatory activity.
    Pyracrenic acid
  • HY-143206
    Tyrosinase/elastase-IN-1
    		Inhibitor
    Tyrosinase/elastase-IN-1 a triterpenoid from Rubus fraxinifolius leaves, has tyrosinase and elastase inhibitory activities.
    Tyrosinase/elastase-IN-1
  • HY-155231
    Neutrophil elastase inhibitor 4
    		Inhibitor
    Neutrophil elastase inhibitor 4 (compound 4f) is a competitive human neutrophil elastase (HNE) inhibitor (IC50: 42.30 nM, Ki: 8.04 nM). Neutrophil elastase inhibitor 4 induces T47D cell apoptosis. Neutrophil elastase inhibitor 4 inhibits cell proliferation with IC50s of 21.25, 34.17, 29.93, 99.11 nM for T47D, RPMI 8226, A549, and HSF cells.
    Neutrophil elastase inhibitor 4
  • HY-106216
    Tiprelestat
    		Inhibitor
    Tiprelestat is a potent human neutrophil elastase inhibitor. Tiprelestat has antimicrobial and anti-inflammatory activities. Tiprelestat can be used in the research of inflammation/immune disease.
    Tiprelestat
  • HY-P4350
    Suc-Ala-Ala-Ala-AMC
    Suc-Ala-Ala-Ala-AMC is a peptide substrate of elastase or elastase-like.
    Suc-Ala-Ala-Ala-AMC
  • HY-124556
    Elasnin
    		Inhibitor
    Elasnin is a selective granulocyte elastase inhibitor. Elasnin is almost ineffective for pancreatic elastase, trypsin, chymotrypsin, thermolysin and papain.
    Elasnin
  • HY-N11564
    Aristololactam IIIa
    		Inhibitor
    Aristololactam IIIa exhibits significant inhibitory effects on superoxide anion generation and elastase release with IC50 values of 0.12 and 0.20 μg/mL, respectively.
    Aristololactam IIIa
  • HY-117668
    MDL 101146
    		Inhibitor
    MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a Ki value of 25 nM. MDL 101146 can be used for the research of arthritis.
    MDL 101146
  • HY-146070
    Elastase-IN-1
    		Inhibitor
    Elastase-IN-1 (Compound Q11) is an elastase inhibitor with an IC50 of 0.897 µM. Elastase-IN-1 is non-toxic.
    Elastase-IN-1
  • HY-111515
    BAY-678 racemate
    		98.30%
    BAY-678 racemate is a racemate of BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).
    BAY-678 racemate
  • HY-163411
    Neutrophil elastase inhibitor 6
    		Inhibitor
    Neutrophil elastase inhibitor 6 (compound 113) is an irreversible phosphonic-type inhibitor of human neutrophil elastase.
    Neutrophil elastase inhibitor 6