Elastase Inhibitor

Elastase Inhibitors (40):

Cat. No.	Product Name	Effect	Purity

HY-17443

Sivelestat	Inhibitor	98.61%
Sivelestat (EI546) is a competitive inhibitor of human neutrophil elastase, with an IC₅₀ of 44 nM and a K_i of 200 nM. Sivelestat (EI546) has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.

HY-15651

Alvelestat	Inhibitor	99.41%
Alvelestat (AZD9668) is an orally bioavailable, affinity and selective inhibitor of neutrophil elastase (NE) with a pIC₅₀ value of 7.9 nM, a K_i value of 9.4 nM and a K_d value of 9.5 nM.

HY-75957

DMP 777	Inhibitor	99.75%
DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.

HY-17443B

Sivelestat sodium tetrahydrate	Inhibitor	99.90%
Sivelestat (EI546) sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, with an IC₅₀ of 44 nM and a K_i of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.

HY-P5995

MeOSuc-AAPA-CMK	Inhibitor
MeOSuc-AAPA-CMK is a potent inhibitor of human neutrophil elastase.

HY-136888

MeOSuc-AAPV-CMK	Inhibitor
MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an elastase inhibitor. MeOSuc-AAPV-CMK also inhibits cathepsin G and proteinase 3.MeOSuc-AAPV-CMK blocks the cleavage of adiponectin by leukocyte elastase.

HY-126988

SP-Chymostatin B	Inhibitor
SP-Chymostatin B (α-MAPI) is a strong inhibitor of many proteases, including chymotrypsin, papain, chymotrypsin-like serine proteinases, chymases, and lysosomal cysteine proteinases such as cathepsins A,B,C, H, and L. SP-Chymostatin B weakly inhibits human leucocyte elastase.

HY-15891A

GW311616 hydrochloride	Inhibitor	98.84%
GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC₅₀ value of 22 nM and K_i value of 0.31 nM.

HY-15891

GW311616	Inhibitor	99.30%
GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC₅₀ value of 22 nM and K_i value of 0.31 nM.

HY-111457A

BAY-678	Inhibitor	99.59%
BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC₅₀ of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).

HY-17443A

Sivelestat sodium	Inhibitor	99.13%
Sivelestat (EI546) sodium is a competitive inhibitor of human neutrophil elastase, with an IC₅₀ of 44 nM and a K_i of 200 nM. Sivelestat (EI546) sodium has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.

HY-N6876

Secologanoside	Inhibitor	≥99.0%
Secologanoside is a triterpenoid isolated from Poraqueiba sericea, weakly inhibits elastase with an IC₅₀ of 164 μg/mL. Secologanoside is moderate cytotoxic to fibroblasts.

HY-P3293A

Lonodelestat TFA	Inhibitor	99.86%
Lonodelestat TFA (POL6014 TFA) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat TFA has the potential for the research of cystic fibrosis (CF).

HY-19254

ZD-0892	Inhibitor
ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with K_is of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase, respectively.

HY-15652A

Freselestat quarterhydrate	Inhibitor	≥99.0%
Freselestat quarterhydrate (ONO-6818 quarterhydrate) is a potent and orally active neutrophil elastase inhibitor with a K_i of 12.2 nM. Freselestat quarterhydrate is >100-fold less-active against other proteases such as trypsin, protein-ase 3, pancreatic elastase, plasmin, thrombin, collagenase, cathepsin G, and murine macrophage elastase. Freselestat quarterhydrate has a potent anti-inflammatory activity.

HY-P3293

Lonodelestat	Inhibitor
Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat (POL6014) has the potential for the research of cystic fibrosis (CF).

HY-19406

AE-3763	Inhibitor	≥98.0%
AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC₅₀ of 29 nM.

HY-N2395

Chrysophanol 8-O-glucoside	Inhibitor	99.26%
Chrysophanol 8-O-glucoside, from the roots of Rumex acetosa, shows moderate elastase inhibition activity.

HY-103445

SSR69071	Inhibitor	≥98.0%
SSR69071 is a potent, orally active and selective inhibitor of neutrophil elastase. SSR69071 reduces myocardial infarct size following ischemia-reperfusion injury. SSR69071 displays a higher affinity for human elastase (K_i=0.0168 nM) than for rat (K_i=3 nM), mouse (K_i=1.8 nM), and rabbit (K_i= 58 nM) elastases.

HY-100240

Lodelaben	Inhibitor
Lodelaben is a human neutrophil elastase inhibitor with an IC₅₀ and K_i of 0.5 and 1.5 μM, respectively.

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