2. Signaling Pathways
  3. Immunology/Inflammation
  4. FLAP
  5. FLAP Antagonist

FLAP Antagonist

FLAP Antagonists (2):

Cat. No. Product Name Effect Purity
  • HY-155407
    ALR-6
    		Antagonist
    ALR-6 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-6 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM and has no significant effect on direct inhibition of 5-LOX.
  • HY-155408
    ALR-27
    		Antagonist
    ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes.