2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. PERK
  5. PERK Activator

PERK Activator

PERK Activators (4):

Cat. No. Product Name Effect Purity
  • HY-119240
    CCT020312
    		Activator 99.28%
    CCT020312 is a selective EIF2AK3/PERK activator. CCT020312 elicits EIF2A phosphorylation in cells.
  • HY-158196
    PERK/eIF2α activator 1
    		Activator
    PERK/eIF2α activator 1 (compound V8) is a flavonoid with an anti-tumor activity. PERK/eIF2α activator 1 induces apoptosis and activates the PERK-eIF2α-ATF4 pathway. PERK/eIF2α activator 1 inhibits HepG2 cell proliferation with an IC50 value of 23 μM.
  • HY-137207
    MK-28
    		Activator 99.50%
    MK-28 is a potent and selective PERK activator. MK-28 exhibits remarkable pharmacokinetic properties and high BBB penetration in mice.
  • HY-101991
    ML291
    		Activator 99.74%
    ML291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide. ML291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden.