Phosphodiesterase (PDE) Inhibitors

PDE1

PDE2

PDE3

PDE4

PDE5

PDE6

PDE7

PDE9

PDE10

PDE11

PDE12

PDE8

Autotaxin

Phosphodiesterase (PDE) Inhibitors, Activators & Modulators

Product Name	PDE1	PDE2	PDE3	PDE4	PDE5	PDE6	PDE7	PDE9	PDE10	PDE11	PDE12	PDE8	Autotaxin	Purity
IBMX			PDE3	PDE4										99.99%
Rolipram				PDE4										99.58%
Roflumilast				PDE4										99.98%
Sildenafil					PDE5									99.97%
PDE7-IN-3							PDE7							99.24%
Theophylline (Standard)			PDE3
Apremilast				PDE4, IC₅₀: 74 nM										99.91%
Icariin				PDE4, IC₅₀: 73.5 μM	PDE5, IC₅₀: 432 nM									99.06%
Theophylline			PDE3											99.89%
Milrinone			PDE3											99.87%
Zatolmilast				PDE4D3, IC₅₀: 7.4 nM PDE4D7, IC₅₀: 7.8 nM										98.98%
Tadalafil					PDE5									99.92%
Ziritaxestat													Autotaxin, IC₅₀: 131 nM Autotaxin, Ki: 15 nM	99.29%
ITI-214	PDE1, Ki: 58 pM PDE1A, Ki: 33 pM PDE1B, Ki: 380 pM PDE1C, Ki: 35 pM													99.54%
Ro 20-1724				PDE4, Ki: 1930 nM										99.34%
EHNA hydrochloride		hPDE2A, IC₅₀: 0.8 μM												99.61%
PF-8380													Autotaxin, IC₅₀: 2.8 nM (In isolated enzyme assay)	99.04%
Sildenafil citrate					PDE5									99.73%
Crisaborole				PDE4
Bay 60-7550		PDE2												98.14%
Edelinontrine								PDE9						98.74%
Butein				PDE4, IC₅₀: 10.4 μM										99.95%
Zaprinast					PDE5									99.95%
DNMDP			PDE3											98.95%
FPFT-2216						PDE6D								99.35%
Avanafil	PDE1, IC₅₀: 53000 nM	PDE2, IC₅₀: 51000 nM		PDE4, IC₅₀: 5700 nM	PDE5, IC₅₀: 5.2 nM	PDE6, IC₅₀: 630 nM	PDE7, IC₅₀: 27000 nM		PDE10, IC₅₀: 6200 nM					≥98.0%
Moracin M				PDE4D2, IC₅₀: 2.9 μM PDE4B2, IC₅₀: 4.5 μM	PDE5A1, IC₅₀: >40 μM			PDE9A2, IC₅₀: >100 μM						98.90%
MR-L2				PDE4										99.23%
Vardenafil	PDE1, IC₅₀: 180 nM		PDE3, IC₅₀: >1000 nM	PDE4, IC₅₀: >1000 nM	PDE5, IC₅₀: 0.7 nM	PDE6, IC₅₀: 11 nM								99.58%
Difamilast				PDE4B, IC₅₀: 11.2 nM										99.63%
Mirodenafil dihydrochloride					PDE5									99.85%
Zardaverine			PDE3	PDE4										98.73%
BAY 2666605			PDE3A, IC₅₀: 87 nM PDE3B, IC₅₀: 50 nM											99.64%
GSK256066				PDE4, IC₅₀: 3.2 pM										98.15%
HA130													Autotaxin, IC₅₀: 28 nM	99.46%
Cilomilast				LPDE4, IC₅₀: ~100 nM HPDE4, IC₅₀: 120 nM										99.89%
PF-05180999		PDE2A, IC₅₀: 1.6 nM					PDE7B, IC₅₀: 50.09 μM		PDE10A1, IC₅₀: 2.03 μM	PDE11A4, IC₅₀: 26.969 μM				99.97%
BC11-38										PDE11, IC₅₀: 0.28 μM				98.13%
Vardenafil hydrochloride	PDE1, IC₅₀: 180 nM		PDE3, IC₅₀: >1000 nM	PDE4, IC₅₀: >1000 nM	PDE5, IC₅₀: 0.7 nM	PDE6, IC₅₀: 11 nM								99.48%
PDE4B-IN-2				PDE4B, IC₅₀: 15 nM PDE4D, IC₅₀: 1.7 μM										99.21%
Tovinontrine	PDE1A3, : 88.4 nM PDE1B, : 8.48 nM PDE1C, : 12.2 nM				PDE5A2, : 81.9 nM			PDE9A1, : 8.19 nM PDE9A2, : 9.99 nM						99.83%
BAY 73-6691								PDE9						99.84%
TMX-4100						PDE6D PDE6								98.42%
PF-05085727		PDE2A, IC₅₀: 2 nM												99.60%
Roflupram				PDE4, IC₅₀: 26.2 nM										99.61%
Orismilast				PDE4B3, IC₅₀: 3 nM PDE4D7, IC₅₀: 3 nM PDE4D5, IC₅₀: 3 nM PDE4B2, IC₅₀: 6 nM PDE4D3, IC₅₀: 8 nM PDE4D4, IC₅₀: 8 nM PDE4D1, IC₅₀: 9 nM PDE4D2, IC₅₀: 9 nM PDE4A4, IC₅₀: 11 nM PDE4B1, IC₅₀: 16 nM PDE4A1, IC₅₀: 16 nM PDE4A10, IC₅₀: 52 nM PDE4C2, IC₅₀: 104 nM										99.37%
Ensifentrine			PDE3, IC₅₀: 0.4 nM	PDE4, IC₅₀: 1479 nM										99.78%
TyK2-IN-2				PDE4, IC₅₀: 62 nM										98.64%
PDE4B-IN-3				PDE4B, IC₅₀: .94 μM										99.40%
Osoresnontrine	PDE1C, IC₅₀: 1 μM PDE1A, IC₅₀: 1.4 μM							PDE9A, IC₅₀: 52 nM						99.88%
PF-04449613								PDE9A, IC₅₀: 22 nM						99.83%
PDE1-IN-2	PDE1A, IC₅₀: 164 nM PDE1B, IC₅₀: 140 nM PDE1C, IC₅₀: 6 nM													≥98.0%
(S)-(+)-Rolipram				PDE4, IC₅₀: 1100 nM										99.77%
GSK356278				PDE4A, pIC₅₀: 8.6 PDE4B, pIC₅₀: 8.8 PDE4D, pIC₅₀: 8.7										99.89%
OR-1896			PDE3/PDE Ⅲ											99.03%
Lodenafil					PDE5									99.81%
Glaucine				PDE4										99.57%
Irsogladine				PDE4										99.97%
TAK-915	PDE1A, IC₅₀: 2497 nM	PDE2A, IC₅₀: 0.61 nM												99.74%
TMX-4113						PDE6D								98.66%
CM-675					PDE5, IC₅₀: 114 nM nM									99.45%
Piclamilast	PDE1, IC₅₀: >100 μM	PDE2, IC₅₀: 40 μM	PDE3, IC₅₀: >100 μM	PDE4, IC₅₀: 16 nM (in pig aorta) PDE4, IC₅₀: 2 nM (in eosinophil soluble)	PDE5, IC₅₀: 14 μM									99.63%
Enoximone			PDE3/PDE Ⅲ, IC₅₀: 5.9 μM	PDE4A, IC₅₀: 21.1 μM (myocardial PDE4A)										98.07%
Mardepodect hydrochloride									PDE10
MK-8189									PDE10A, Ki: 29 pM					99.88%
Dovramilast				PDE4 PDE4										99.83%
FCPR03				PDE4 catalytic domain, IC₅₀: 60 nM PDE4B1, IC₅₀: 31 nM PDE4D7, IC₅₀: 47 nM										99.82%
PF-06445974				PDE4B, IC₅₀: <1 nM PDE4D, IC₅₀: 36 nM PDE4A, IC₅₀: 4.7 nM PDE4C, IC₅₀: 17 nM										98.23%
Thioquinapiperifil dihydrochloride	PDE1, IC₅₀: 380 nM	PDE2, IC₅₀: 670 nM	PDE3, IC₅₀: 38 nM	PDE4, IC₅₀: 800 nM	PDE5, IC₅₀: 0.074 nM									99.22%
Oglemilast				PDE4D3, IC₅₀: .5 nM										98.00%
PAT-505													Autotaxin, IC₅₀: 2 nM (In Hep3B cells) Autotaxin, IC₅₀: 9.7 nM (In human blood ) Autotaxin, IC₅₀: 62 nM (In mouse plasma)	99.47%
PDE12-IN-3											PDE12, pXC₅₀: 7.68			99.43%
MY-5445				PDE4, IC₅₀: 37 μM	PDE5, IC₅₀: 6.7 μM PDE5, Ki: 1.3 μM									99.86%
CI-1044				PDE4A5, IC₅₀: 0.29 μM PDE4B2, IC₅₀: 0.08 μM PDE4C2, IC₅₀: 0.56 μM PDE4D3, IC₅₀: 0.09 μM										98.03%
Sp-cAMPS sodium salt			PDE3A, Ki: 47.6 μM						PDE10 GAF domain, EC₅₀: 50 μM					98.73%
Mirodenafil					PDE5									99.70%
Autotaxin modulator 1													Autotaxin	98.93%
K-Ras-PDEδ-IN-1				PDE4, Kd: 8.3 nM										99.62%
PDE12-IN-1											PDE12, pIC₅₀: 9.1			99.23%
Autotaxin-IN-3													Autotaxin, IC₅₀: 2.4 nM	98.24%
MBCQ	PDE Ⅰ, IC₅₀: >100 μM	PDE Ⅱ, IC₅₀: >100 μM	PDE Ⅲ, IC₅₀: >100 μM	PDE Ⅳ, IC₅₀: >100 μM	PDE V, IC₅₀: 19 nM									99.37%
RS-25344 hydrochloride	PDE Ⅰ, IC₅₀: >100 μM	PDE Ⅱ, IC₅₀: 160 μM	PDE Ⅲ, IC₅₀: 330 μM	PDE Ⅳ, IC₅₀: 0.28 nM										99.50%
Nortadalafil					PDE5									99.77%
Motapizone			PDE3
PQ-10									PDE10A, IC₅₀: 4.6 nM					99.77%
PDE10A-IN-2 hydrochloride									PDE10A, IC₅₀: 2.8 nM					98.43%
BRD9500			PDE3A, IC₅₀: 10 nM PDE3B, IC₅₀: 27 nM											99.46%
LEO 39652				PDE4D, IC₅₀: 3.8 nM PDE4A, IC₅₀: 1.2 nM PDE4B, IC₅₀: 1.2 nM PDE4C2, IC₅₀: 3.0 nM										99.51%
ATX inhibitor 5													Autotaxin	99.20%
PDE5-IN-7	PDE1, IC₅₀: 300 nM				PDE5, IC₅₀: 5 nM									99.59%
Fenspiride hydrochloride			PDE3	PDE4	PDE5									99.97%
Sp-cAMPS			PDE3A, Ki: 47.6 μM						PDE10 GAF domain, EC₅₀: 50 μM
Kuraridine					PDE5, IC₅₀: 0.64 μM									≥98.0%
Sildenafil-d₃					PDE5									99.79%
Ayanin		PDE2A		PDE4										98.00%
Gisadenafil besylate	PDE1A, IC₅₀: 9.1 μM				PDE5A, IC₅₀: 3.6 nM									≥99.0%
PDE2/PDE10-IN-1		hPDE2A, IC₅₀: 29 nM		hPDE4D, IC₅₀: 5890 nM					rPDE10A, IC₅₀: 480 nM	hPDE11A, IC₅₀: 6920 nM				99.88%
AN3199				PDE4, IC₅₀: 94.5 nM										99.67%
Tetomilast				PDE4										≥98.0%
ent-Tadalafil					PDE5, IC₅₀: 10 μM									98.14%
Lirimilast				PDE4, IC₅₀: 42 nM										98.69%
BIO-32546													Autotaxin	99.05%
PDE9-IN-1								PDE9A, IC₅₀: 8.7 nM						99.70%
BW-A 78U				PDE4, IC₅₀: 3 μM										99.67%
PDE4-IN-4				PDE4
Robustine					PDE5A									99.97%
Lodenafil carbonate					PDE5									≥98.0%
MK-0952				PDE4, IC₅₀: 0.53 nM										99.71%
Yonkenafil hydrochloride					PDE5									99.43%
Sophoflavescenol					PDE5									98.15%
Hcyb1		PDE2												98.24%
PDE5-IN-4					PDE5
PDE10-IN-1									PDE10					99.44%
T-0156	PDE1, IC₅₀: >100 μM	PDE2, IC₅₀: >100 μM	PDE3, IC₅₀: >100 μM	PDE4, IC₅₀: 63 μM	PDE5, IC₅₀: 0.23 nM	PDE6, IC₅₀: 56 nM
S32826 disodium													Autotaxin, IC₅₀: 8.8 nM	99.23%
PF-8380 hydrochloride													Autotaxin, IC₅₀: 2.8 nM (In isolated enzyme assay)	98.59%
ITI-214 free base	PDE1, Ki: 58 pM PDE1A, Ki: 33 pM PDE1B, Ki: 380 pM PDE1C, Ki: 35 pM													≥98.0%
LASSBio-1632				PDE4A PDE4D
PF-07038124				PDE4B2, IC₅₀: 0.5 nM
Vardenafil dihydrochloride	PDE1, IC₅₀: 180 nM				PDE5, IC₅₀: 0.7 nM	PDE6, IC₅₀: 11 nM
Avanafil dibenzenesulfonate	PDE1, IC₅₀: 53000 nM	PDE2, IC₅₀: 51000 nM		PDE4, IC₅₀: 5700 nM	PDE5, IC₅₀: 5.2 nM	PDE6, IC₅₀: 630 nM	PDE7, IC₅₀: 27000 nM		PDE10, IC₅₀: 6200 nM
TPN729MA	PDE1, IC₅₀: 566 nM			PDE4, IC₅₀: 834 nM	PDE5, IC₅₀: 2.28 nM	PDE6, IC₅₀: 45.2 nM				PDE11, IC₅₀: 6090 nM				99.45%
TPN729	PDE1, IC₅₀: 566 nM			PDE4, IC₅₀: 834 nM	PDE5, IC₅₀: 2.28 nM	PDE6, IC₅₀: 45.2 nM				PDE11, IC₅₀: 6090 nM
Autotaxin-IN-4													Autotaxin
PDE5-IN-2		PDE2A, IC₅₀: 106 nM		PDE4D2, IC₅₀: 43 nM	PDE5A1, IC₅₀: 0.31 nM	PDE6C, IC₅₀: 1.2 nM			PDE10A, IC₅₀: 46 nM
TPN171					PDE5, IC₅₀: 0.62 nM									99.41%
BAY-7081								PDE9A, IC₅₀: 15 nM
MT-3014									human PDE 10A, IC₅₀: 0.062 nM bovine PDE 10A, IC₅₀: 0.09 nM
Sp-cAMPS triethylamine			PDE3A, Ki: 47.6 μM						PDE10 GAF domain, EC₅₀: 50 μM
(S)-C33	PDE1B, IC₅₀: 554 ± 64 nM	PDE2A, IC₅₀: 2.4 ± 0.5 μM		PDE4D2, IC₅₀: 1.3 ± 0.1 μM	PDE5A1, IC₅₀: 366 ± 38 nM			PDE9A, IC₅₀: 11 ± 4 nM	PDE10A1, IC₅₀: 2.3 ± 0.3 μM
Gemlapodect									PDE10A
PDE11-IN-1										PDE11				98.23%
PDE4-IN-6				PDE4B, IC₅₀: 0.125 μM PDE4D, IC₅₀: 0.43 μM
Thioquinapiperifil	PDE1, IC₅₀: 380 nM	PDE2, IC₅₀: 670 nM	PDE3, IC₅₀: 38 nM	PDE4, IC₅₀: 800 nM	PDE5, IC₅₀: 0.074 nM
Deltazinone 1						PDEδ, Kd: 8 nM
PDE11A4-IN-1										PDE11A4, IC₅₀: 12 nM
S32826													Autotaxin, IC₅₀: 8.8 nM
PDE5-IN-3					PDE5, IC₅₀: 1.57 nM
Z21090				PDE4, IC₅₀: 37.4 nM
PF-03049423 free base					PDE5A
ATX inhibitor 18													Autotaxin, IC₅₀: 24.2 nM
Toddacoumalone				PDE4
PDE4-IN-12				PDE4D2, IC₅₀: 3.51 nM PDE4B2, IC₅₀: 9.51 nM	PDE5A1, IC₅₀: 1.24 μM		PDE7A, IC₅₀: 15 nM		PDE10A, IC₅₀: 1.02 μM			PDE8A1, IC₅₀: 194 nM
FR-229934					PDE V									98.65%
Gisadenafil	PDE1A, IC₅₀: 9.1 μM				PDE5A, IC₅₀: 3.6 nM
(R)-Irsenontrine								PDE9, IC₅₀: 0.041 μM						99.00%
PDE5-IN-9					PDE5									≥98.0%
ATX inhibitor 20													Autotaxin, IC₅₀: 2.3 ± 0.31 nM
ATX inhibitor 15													Autotaxin, IC₅₀: 2.17 nM
PDE5/HDAC-IN-1					PDE5, IC₅₀: 46.3 nM
Norbraylin				PDE4D2, IC₅₀: 7.15 μM
N-Methylbenzamide									PDE10A					99.82%
ATX inhibitor 12													Autotaxin, IC₅₀: 1.72 nM
Atizoram				PDE4
Anagrelide hydrochloride monohydrate			PDE3
ICI-63197	PDE Ⅰ, Ki: 487 μM	PDE Ⅱ, Ki: >1000 μM	PDE3/PDE Ⅲ, Ki: 9 μM	PDE Ⅳ, Ki: 10 μM
PDE3B-IN-1			PDE3B, IC₅₀: 6.5 μM
PDE4-IN-11				PDE4
ATX inhibitor 19													Autotaxin, IC₅₀: 156 ± 19.8 nM
ATX inhibitor 14													Autotaxin, IC₅₀: 0.41 nM
PDE2A-IN-1		PDE2
Arofylline				PDE4
Ilexsaponin B2	PDEI, IC₅₀: 477.5 μM				PDE5, IC₅₀: 48.8 μM
Autotaxin-IN-1													Autotaxin, IC₅₀: 2 nM
ATX inhibitor 8													Autotaxin
Icariin (Standard)				PDE4	PDE5
Acetildenafil					PDE5
PDE7-IN-2							PDE7A, IC₅₀: 2.1 μM
PDE5-IN-10					PDE5, IC₅₀: 20 nM
JNJ-42314415									human PDE 10A, Ki: 35 nM
1,3,5-Trihydroxy-4-prenylxanthone					PDE5, IC₅₀: 3 μM
PF-00489791					PDE5A, IC₅₀: 5 nM
Mesembrine				PDE4B, IC₅₀: 7.8 μM
cis-Tadalafil					PDE5, IC₅₀: 0.09 μM
CDP-840				PDE4
Autotaxin-IN-5													Autotaxin
Fenspiride			PDE3	PDE4	PDE5
Etazolate hydrochloride				PDE4, IC₅₀: 2 μM
PDE4-IN-5				PDE4
Autotaxin-IN-6													Autotaxin, IC₅₀: 30 nM
MHC00188													Autotaxin
ATX inhibitor 11													Autotaxin, IC₅₀: 2.7 ± 1 nM
PDE4-IN-8				PDE4B2, IC₅₀: 0.93 nM
Avanafil-¹³C,d₃	PDE1
Mesopram				PDE4
Theophylline sodium acetate			PDE3
PDE4-IN-13				PDE4, IC₅₀: 1.56 μM
TC-E 5005		PDE2A, IC₅₀: 239 nM	PDE3A, IC₅₀: 3700 nM		PDE5A, IC₅₀: 919 nM		PDE7B, IC₅₀: 3100 nM		PDE10A, IC₅₀: 7.28 nM	hPDE11A, IC₅₀: 779 nM
PDE4B/7A-IN-1				PDE4			PDE7
AChE/PDE4-IN-1				PDE4, IC₅₀: 1.88 μM
PDE4B/7A-IN-2				PDE4			PDE7
PDE5-IN-5					PDE5, IC₅₀: 2.0 nM
ATX inhibitor 21													Autotaxin, IC₅₀: 3490 ± 170 nM
L-869298				PDE4A, IC₅₀: 0.5 nM
PDE5-IN-12					PDE5, IC₅₀: 22 nM
PF-03049423					PDE5A
PDE1-IN-4	PDE1C, IC₅₀: 10 ± 3 nM PDE1A, IC₅₀: 145 nM PDE1B, IC₅₀: 354 nM	PDE2A, IC₅₀: 5130 nM	PDE3A, IC₅₀: >10000 nM	PDE4B2, IC₅₀: 619 nM PDE4D2, IC₅₀: 948 nM	PDE5A1, IC₅₀: 1810 nM			PDE9A2, IC₅₀: >10000 nM	PDE10A, IC₅₀: 1310 nM
PDE4-IN-10				PDE4B, IC₅₀: 7.01 ± 1.0 μM
ATX inhibitor 22													Autotaxin, IC₅₀: 218 nM
MEY-003													Autotaxin
Irsogladine maleate				PDE4
Olprinone	PDE1, IC₅₀: 150 μM	PDE2, IC₅₀: 100 μM	PDE3, IC₅₀: 0.35 μM	PDE4, IC₅₀: 14 μM										99.29%

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