VD/VDR

Vitamin D; Vitamin D receptor

VD/VDR

Related Products

Vitamin D is a secosteroidalprohormone, it can be synthesized at sufficient levels in skin, given adequate skin exposure to UV B radiation from sunlight. Vitamin D modulates its biological effects by directly regulating target gene expression through the Vitamin D receptor (VDR), a ligand-regulated transcription factor and a member of the nuclear receptor superfamily. Whether synthesized in the skin or ingested, vitamin D requires two hydroxylation steps to become the biologically active hormone, 1,25-dyhydroxyvitamin D₃ [1,25(OH)₂D₃], a form that signals through the VDR. The hormone-bound VDR modulates target gene transcription in response to vitamin D. VDR acts as a master transcriptional regulator of autophagy. Activation of the VDR by vitamin D induces autophagy and an autophagic transcriptional signature in breast cancer (BC) cells.

There are 2 forms of vitamin D. Vitamin D₂ (ergocalciferol) comes from irradiation of the yeast and plant sterol ergosterol, and vitamin D₃ (cholecalciferol) is found in oily fish and cod liver oil and is made in the skin. Vitamin D represents vitamin D₂ and vitamin D₃.

Topical agents containing active vitamin D₃ (calcitriol, 1α, 25- dihydroxyvitaminD₃, VD₃) analogues such as Tacalcitol, Calcipotriol and Maxacalcitol are widely used for psoriasis therapy.

VD/VDR Related Products (92)
Antibodies (2)

By Effects:	Inhibitors (2) Agonists (10) Antagonists (3) Activators (53) Modulators (2) Chemicals (3)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-13332

Calcifediol-d₆	Activator	98.91%
Calcifediol-d₆ is the deuterium labeled Calcifediol. Calcifediol, a major circulating metabolite of vitamin D3, is a potent VDR inhibitor[1][2].

HY-15830

25,26-Dihydroxyvitamin D3	Activator
25,26-Dihydroxyvitamin D3(25,26-dihydroxycholecalciferol) is a metabolite of vitamin D3 with intestinal calcium transport activity.

HY-15332

Alfacalcidol-d₆	Activator	≥98.0%
Alfacalcidol-d₆ is the deuterium labeled Alfacalcidol. Alfacalcidol is a non-selective VDR activator.

HY-76585

Paricalcitol-d₆	Activator	99.64%
Paricalcitol-d₆ is the deuterium labeled Paricalcitol. Paricalcitol is a agent used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure[1].

HY-32351S

Calcifediol-d₃		99.06%
Calcifediol-d₃ is a deuterium labeled Calcifediol. Calcifediol, a major circulating metabolite of vitamin D3, is a potent VDR ligand.

HY-32342

Falecalcitriol	Activator
Falecalcitriol(Fulstan; Hornel) is an analog of calcitriol; has a higher potency both in vivo and in vitro systems, and longer duration of action in vivo.

HY-13294

Impurity C of Alfacalcidol	Activator	99.81%
Impurity of Alfacalcidol. Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator medication.

HY-10002A

(1S)-Calcitriol		98.31%
(1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D₃ (1α,25(OH)₂D₃). (1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion.

HY-15329

Maxacalcitol-d₆	Activator	99.63%
Maxacalcitol-d₆6 is the deuterated form of Maxacalcitol (22-Oxacalcitriol), which is a non-calcemic vitamin D3 analog and VDR ligand of VDR-like receptors.

HY-32346

Atocalcitol		98.02%
Atocalcitol, a vitamin D3 analogue, is used in the study for psoriasis.

HY-13293

Impurity C of Calcitriol	Activator	99.84%
Impurity C of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-13292

Impurity B of Calcitriol	Activator	98.04%
Impurity B of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-13249

1alpha-Hydroxy VD4	Activator	98.41%
1alpha-Hydroxy VD4 , a 1alpha(OH)D derivative, can effectively induce the differentiation of monoblastic leukaemia U937, P39/TSU and P31/FUJ cells.

HY-76542S

Vitamin D2-d₆	Activator
Vitamin D2-d₆ is the deuterium labeled Vitamin D2. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D[1][2].

HY-15285

Doxercalciferol-d₃	Activator
Doxercalciferol-d₃3 is the deuterated form of Doxercalciferol, which is a Vitamin D2 analog that acts as a vitamin D receptor activator (VDRA).

HY-130705

Previtamin D3		98.68%
Previtamin D3 is an intermediate in the production of cholecalciferol (vitamin D3).

HY-32340

Lexacalcitol	Activator	99.42%
Lexacalcitol (KH1060), a vitamin D analog, is a potent regulator of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases.

HY-76937

Impurity of Doxercalciferol	Activator
Impurity of Doxercalciferol is an impurity of doxercalciferol, which is a synthetic analog of ergocalciferol (vitamin D2), used as a agent for secondary hyperparathyroidism and metabolic bone disease, and it suppresses parathyroid synthesis and secretion.

HY-15156

1alpha, 24, 25-Trihydroxy VD2	Activator	98.21%
1alpha, 24, 25-Trihydroxy VD2 is a vitamin D analog.

HY-131961

Triciferol	Agonist	98.61%
Triciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR (IC₅₀=87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities.

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VD/VDR

VD/VDR

VD/VDR Related Products (92)

Antibodies (2)

VD/VDR Related Products (92):