2. Signaling Pathways
  3. Immunology/Inflammation
  4. BCL6

BCL6

B-cell lymphoma 6 protein; B-cell lymphoma 5 protein (BCL-5); Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51

 

BCL6 Related Products (5):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-156595
    BCL6 ligand-1
    		99.17%
    BCL6 ligand-1 (compound I-94) is a ligand for TCIP 1 (HY-156531). TCIP 1 is a BCL6 inhibitor that activates apoptosis and is used in cancer research.
    BCL6 ligand-1
  • HY-143653
    BCL6-IN-6
    		98.39%
    BCL6-IN-6 is a potent inhibitor of transcriptional repressor B-cell lymphoma 6 (BCL6). BCL6-IN-6 significantly blocks the interaction of BCL6 with its corepressors and reactivates BCL6 target genes in a dose-dependent manner. BCL6-IN-6 has the potential for the research of diffuse large B-cell lymphoma (DLBCL).
    BCL6-IN-6
  • HY-158105
    ARV-393
    		Degrader
    ARV-393 is an orally active PROTAC that utilizes the ubiquitin-proteasome system to target the degradation of BCL6. ARV-393 consists of ligand conjugates targeting BCL6 and the E3 ligase cereblon, respectively. ARV-393 has DC50 and GI50 values of <1 nM in multiple cell lines of diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). ARV-393 also demonstrated considerable tumor suppressor activity in tumor xenograft models. ARV-393 is being studied to inhibit non-Hodgkin lymphoma.
    ARV-393
  • HY-153521
    CCT374705
    		Inhibitor 99.30%
    CCT374705 is an orally active BCL6 inhibitor with potent antiproliferative effects in vitro. CCT374705 effectively inhibits tumor growth in a lymphoma xenograft mouse model.
    CCT374705
  • HY-161138
    WK369
    		Inhibitor
    WK369 is a novel BCL6 small molecule inhibitor, which exhibits excellent anti-ovarian cancer bioactivity, induces cell cycle arrest and causes apoptosis. WK369 can directly bind to the BCL6-BTB domain and block the interaction between BCL6 and SMRT, leading to the reactivation of p53, ATR and CDKN1A.
    WK369