2. Signaling Pathways
  3. Anti-infection
  4. Dengue virus

Dengue virus

DENV

 

Dengue virus Related Products (65):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16696
    SN 2
    		Inhibitor 99.16%
    SN 2 is a potent activator of TRPML3 ion channel with an EC50 of 1.8 μM. SN 2 also acts as a potent inhibitor of Dengue virus 2 (DENV2) and Zika virus (ZIKV).
    SN 2
  • HY-138543
    NITD-688
    		Inhibitor 99.00%
    NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV).
    NITD-688
  • HY-W011100
    Cyclofenil
    		Inhibitor
    Cyclofenil is a selective estrogen receptor modulator and an ovulation-inducing agent. Cyclofenil shows an inhibitory effect on dengue virus replication in Vero cells with an EC50 of 1.62 μM. Cyclofenil has anti-dengue-virus activity.
    Cyclofenil
  • HY-124801
    ABMA
    		Inhibitor 98.68%
    ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite. ABMA selectively acts at host cell late endosomes rather than targeting toxin or pathogen itself. ABMA has broad-spectrum anti-infection activity.
    ABMA
  • HY-124662
    IHVR-19029
    		Inhibitor ≥98.0%
    IHVR-19029 is a potent endoplasmic reticulum (ER) α-glucosidases I and II inhibitor, with an IC50 of 0.48 μM for ER a-glucosidase I. IHVR-19029 efficiently blocks the replication of several hemorrhagic fever viruses, such as Dengue virus (DENV), Ebola virus (EBOV) and Rift Valley fever virus. The combination of IHVR-19029 with Favipiravir (HY-14768) improves the antiviral efficacy.
    IHVR-19029
  • HY-16134A
    Celgosivir hydrochloride
    		Inhibitor ≥98.0%
    Celgosivir hydrochloride (MBI 3253 hydrochloride; MDL 28574 hydrochloride; MX3253 hydrochloride) is an α-glucosidase I inhibitor; inhibits bovine viral diarrhoea virus (BVDV) with an IC50 of 1.27 μM in in vitro assay.
    Celgosivir hydrochloride
  • HY-121138
    1,8-Dihydroxy-4,5-dinitroanthraquinone
    		Inhibitor 98.00%
    1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM.
    1,8-Dihydroxy-4,5-dinitroanthraquinone
  • HY-117430
    Hymeglusin
    		Inhibitor ≥98.0%
    Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC50 = 0.12 μM). Hymeglusin covalently modifies the active Cys129 residue of the enzyme.
    Hymeglusin
  • HY-U00160
    SP187
    		Inhibitor 99.30%
    SP187 is a host-targeted iminosugar with activity against filovirus infections in vitro and in vivo. SP187 is active against influenza and dengue in vivo.
    SP187
  • HY-100540B
    Golgicide A-2
    		Inhibitor 99.53%
    Golgicide A-2 (GCA-2), a Golgicide A (GCA) derivative, is the most active enantiomer of GCA. Golgicide A-2 displays high selectivity and efficiency in killing An. stephensi larvae and can be used for the research of dengue virus related diseases.
    Golgicide A-2
  • HY-126113
    KIN101
    		Inhibitor 99.36%
    KIN101 is a potent RNA viral inhibitor with IC50s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses.
    KIN101
  • HY-132174
    CHIKV-IN-2
    		Inhibitor 98.15%
    CHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV), with excellent cellular antiviral activity (EC90=270 nM) and improved liver microsomal stability. CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydrogenase (DHODH), which interacts with various viruses and regulate their replication via depleting intracellular pyrimidine pools.
    CHIKV-IN-2
  • HY-109571
    HZ-1157
    		Inhibitor 98.75%
    HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent.
    HZ-1157
  • HY-124645
    QL-X-138
    		Inhibitor 99.77%
    QL-X-138 is a potent and selective BTK/MNK dual kinase inhibitor, exhibits covalent binding to BTK and non-covalent binding to MNK. QL-X-138 shows IC50s of 9.4 nM, 107.4 nM and 26 nM for BTK, MNK1 and MNK2 kinases respectively. QL-X-138 also shows anti-dengue virus 2 activity, with an IC50 of 3.5 μM. QL-X-138 can be used for the research of B-cell malignancies.
    QL-X-138
  • HY-N0100S
    Naringenin-d4
    		Inhibitor ≥98.0%
    Naringenin-d4 is the deuterated version of Naringenin (HY-N0100). Naringenin shows strong anti-inflammatory and antioxidant activities. Naringenin has anti-dengue virus (DENV) activity[1].
    Naringenin-d<sub>4</sub>
  • HY-124618A
    FGI-106 tetrahydrochloride
    		Inhibitor 99.68%
    FGI-106 tetrahydrochloride is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI-106 tetrahydrochloride is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 tetrahydrochloride also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC50s of 200 nM and 150 nM, respectively.
    FGI-106 tetrahydrochloride
  • HY-134665
    NITD-2
    		Inhibitor 99.62%
    NITD-2, a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 penetrates cell membrane poorly.
    NITD-2
  • HY-16134
    Celgosivir
    		Inhibitor
    Celgosivir (MBI 3253; MDL 28574; MX3253) is an α-glucosidase I inhibitor; inhibits bovine viral diarrhoea virus (BVDV) with an IC50 of 1.27 μM in in vitro assay.
    Celgosivir
  • HY-108908
    (Rac)-Modipafant
    		Inhibitor 98.15%
    (Rac)-Modipafant (UK-74505) is an orally active, selective, long-acting irreversible platelet activating factor receptor (PAFR) antagonist. (Rac)-Modipafant prevents dengue infection.
    (Rac)-Modipafant
  • HY-N3942
    Glabranine
    		Inhibitor ≥98.0%
    Glabranine, an flavonoid, is isolated from Tephrosia s.p, exerts a inhibitory effect in vitro on the dengue virus. Glabranine forms interaction with the soluble ectodomain of DENV type 2 (DENV2) E protein.
    Glabranine