1. Metabolic Enzyme/Protease
  2. Renin
  3. VTP-27999 Hydrochloride

VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.

For research use only. We do not sell to patients.

VTP-27999 Hydrochloride Chemical Structure

VTP-27999 Hydrochloride Chemical Structure

CAS No. : 1264191-73-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 159 In-stock
Solution
10 mM * 1 mL in Water USD 159 In-stock
Solid
5 mg USD 129 In-stock
10 mg USD 200 In-stock
50 mg USD 640 In-stock
100 mg USD 1020 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Other Forms of VTP-27999 Hydrochloride:

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Description

VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases. IC50 value: Target: Renin

Clinical Trial
Molecular Weight

561.54

Formula

C26H42Cl2N4O5

CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(NC[C@H](C[C@@H]1COCCC1)NC)N(CCC2)C[C@]2([H])[C@](OCCNC(OC)=O)([H])C3=CC(Cl)=CC=C3.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (178.08 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7808 mL 8.9041 mL 17.8082 mL
5 mM 0.3562 mL 1.7808 mL 3.5616 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.18%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.7808 mL 8.9041 mL 17.8082 mL 44.5204 mL
5 mM 0.3562 mL 1.7808 mL 3.5616 mL 8.9041 mL
10 mM 0.1781 mL 0.8904 mL 1.7808 mL 4.4520 mL
15 mM 0.1187 mL 0.5936 mL 1.1872 mL 2.9680 mL
20 mM 0.0890 mL 0.4452 mL 0.8904 mL 2.2260 mL
25 mM 0.0712 mL 0.3562 mL 0.7123 mL 1.7808 mL
30 mM 0.0594 mL 0.2968 mL 0.5936 mL 1.4840 mL
40 mM 0.0445 mL 0.2226 mL 0.4452 mL 1.1130 mL
50 mM 0.0356 mL 0.1781 mL 0.3562 mL 0.8904 mL
60 mM 0.0297 mL 0.1484 mL 0.2968 mL 0.7420 mL
80 mM 0.0223 mL 0.1113 mL 0.2226 mL 0.5565 mL
100 mM 0.0178 mL 0.0890 mL 0.1781 mL 0.4452 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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VTP-27999 Hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
VTP-27999 Hydrochloride
Cat. No.:
HY-76652
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