2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel Apoptosis
  3. Endogenous Metabolite iGluR Ferroptosis Apoptosis
  4. L-Glutamic acid

L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases.

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L-Glutamic acid Chemical Structure

L-Glutamic acid Chemical Structure

CAS No. : 56-86-0

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Solid + Solvent
10 mM * 1 mL in Water
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Based on 3 publication(s) in Google Scholar

Other Forms of L-Glutamic acid:

L-Glutamic acid Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases[1][2][3][4][5].

IC50 & Target[1]

DA

 

Human Endogenous Metabolite

 

Microbial Metabolite

 

In Vitro

L-Glutamic acid (120, 500, 750, 1000 mg/dL) can reduce the harmful effect of lithium on the embryonic development of Xenopus Xenopus[3].
L-Glutamic acid (2, 5, 10, 20 mM, 24-48 h) can induce neuroexcitotoxicity in neuroblastoma[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Glutamic acid Related Antibodies

Cell Viability Assay[4]

Cell Line: SH-SY5Y, IMR-32, SK-N-BE(2)
Concentration: 2, 5, 10, 20 mM
Incubation Time: 24 and 48 h
Result: Reduced cell viability in a dose-dependent manner.
In Vivo

L-Glutamic acid (3 g/kg, subcutaneous injection) can promote excitotoxic degeneration of retinal ganglion cells in mice[1].
L-Glutamic acid (750 mg/kg, intraperitoneal injection) can reduce and inhibit oxidative stress induced by chlorpyrifos (CPF) in rats[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Crv4 mice model[1]
Dosage: 3 g/kg
Administration: s.c., single dose
Result: Reduced the number of Brn-3a+ RGCs by >70%.
In the absence of mGlu1 receptor, MSG-induced retinal damage is diminished.
Animal Model: CPF-induced rat model[5]
Dosage: 750 mg/kg
Administration: i.p.
Result: Reduced CPF-induced oxidative stress by increasing the level of GSH and activity of GSH-related enzymes.
Molecular Weight

147.13

Formula

C5H9NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(CC[C@H](N)C(O)=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 6.25 mg/mL (42.48 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.7967 mL 33.9836 mL 67.9671 mL
5 mM 1.3593 mL 6.7967 mL 13.5934 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 9.09 mg/mL (61.78 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.43%

COA (250 KB) HNMR (150 KB) RP-HPLC (145 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.7967 mL 33.9836 mL 67.9671 mL 169.9178 mL
5 mM 1.3593 mL 6.7967 mL 13.5934 mL 33.9836 mL
10 mM 0.6797 mL 3.3984 mL 6.7967 mL 16.9918 mL
15 mM 0.4531 mL 2.2656 mL 4.5311 mL 11.3279 mL
20 mM 0.3398 mL 1.6992 mL 3.3984 mL 8.4959 mL
25 mM 0.2719 mL 1.3593 mL 2.7187 mL 6.7967 mL
30 mM 0.2266 mL 1.1328 mL 2.2656 mL 5.6639 mL
40 mM 0.1699 mL 0.8496 mL 1.6992 mL 4.2479 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Glutamic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Glutamic acid56-86-0Endogenous MetaboliteiGluRFerroptosisApoptosisIonotropic glutamate receptorsNMDAAgonistSH-SY5YIMR-32SK-N-BE(2)NeurotoxicityCrv4 miceInhibitorinhibitorinhibit

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