1. Anti-infection
  2. Bacterial
  3. β-Chloro-L-alanine

β-Chloro-L-alanine  (Synonyms: L-β-Chloroalanine)

Cat. No.: HY-107373 Purity: ≥98.0%
COA Handling Instructions

β-Chloro-L-alanine is a bacteriostatic amino acid analog which inhibits a number of enzymes, including threonine deaminase and alanine racemase.

For research use only. We do not sell to patients.

β-Chloro-L-alanine Chemical Structure

β-Chloro-L-alanine Chemical Structure

CAS No. : 2731-73-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
USD 55 In-stock
Solution
10 mM * 1 mL in Water USD 55 In-stock
Solid
100 mg USD 50 In-stock
250 mg USD 75 In-stock
500 mg   Get quote  
1 g   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of β-Chloro-L-alanine:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

β-Chloro-L-alanine is a bacteriostatic amino acid analog which inhibits a number of enzymes, including threonine deaminase and alanine racemase.

IC50 & Target

Bacterial[1]

In Vitro

β-Chloro-L-alanine can inhibit threonine deaminase, the branched-chain amino acid transaminase (transaminase B), L-aspartate-pdecarboxylase, alanine racemase and probably O-acetylserine sulfhydrylase. β-Chloro-L-alanine reversibly inhibits the Escherichia coli K-12 alanine-valine transaminase, transaminase C. This inhibition, along with the inhibition of transaminase B, account for the isoleucine-plus-valine requirement of Escherichia coli in the presence of β-Chloro-L-alanine. Salmonella typhimurium LT2 will grow in the presence of BCA if isoleucine and valine are added to the medium and presume that the growth requirement is due to the inhibition of transaminase B[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

123.54

Formula

C3H6ClNO2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H](N)CCl)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : ≥ 30 mg/mL (242.84 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.0945 mL 40.4727 mL 80.9454 mL
5 mM 1.6189 mL 8.0945 mL 16.1891 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (404.73 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 8.0945 mL 40.4727 mL 80.9454 mL 202.3636 mL
5 mM 1.6189 mL 8.0945 mL 16.1891 mL 40.4727 mL
10 mM 0.8095 mL 4.0473 mL 8.0945 mL 20.2364 mL
15 mM 0.5396 mL 2.6982 mL 5.3964 mL 13.4909 mL
20 mM 0.4047 mL 2.0236 mL 4.0473 mL 10.1182 mL
25 mM 0.3238 mL 1.6189 mL 3.2378 mL 8.0945 mL
30 mM 0.2698 mL 1.3491 mL 2.6982 mL 6.7455 mL
40 mM 0.2024 mL 1.0118 mL 2.0236 mL 5.0591 mL
50 mM 0.1619 mL 0.8095 mL 1.6189 mL 4.0473 mL
60 mM 0.1349 mL 0.6745 mL 1.3491 mL 3.3727 mL
80 mM 0.1012 mL 0.5059 mL 1.0118 mL 2.5295 mL
100 mM 0.0809 mL 0.4047 mL 0.8095 mL 2.0236 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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β-Chloro-L-alanine Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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β-Chloro-L-alanine
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