2. Protein Tyrosine Kinase/RTK Antibody-drug Conjugate/ADC Related
  3. c-Met/HGFR ADC Antibody
  4. ABBV-303

ABBV-303 is a multi-specific NK cell antibody targeting c-Met designed based on TriNKET technology for natural killer (NK) cell redirection therapy. The ABBV-303 antibody consists of three functional arms, a single-chain variable fragment (scFV) targeting c-Met, a Fab arm targeting NKG2D, and an Fc fragment targeting NK cell CD16a.

For research use only. We do not sell to patients.

ABBV-303 Chemical Structure

ABBV-303 Chemical Structure

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ABBV-303 Related Antibodies

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Description

ABBV-303 is a multi-specific NK cell antibody targeting c-Met designed based on TriNKET technology for natural killer (NK) cell redirection therapy. The ABBV-303 antibody consists of three functional arms, a single-chain variable fragment (scFV) targeting c-Met, a Fab arm targeting NKG2D, and an Fc fragment targeting NK cell CD16a[1].

In Vitro

Introduction of the three functional arms of ABBV-303[1]:
(1) Single-chain variable fragment (scFV): scFV based on ABT-700 (HY-P99391), also c-Met< /b> Targeted antibody-drug conjugates (ADCs) The consensus fragment of ABBV-400 and Teliso-V;
(2) Fab arm: targeting NKG2D, used to bind and activate NK cells expressing NKG2D CD8+ T cells;
(3) Conventional Fc fragment: heterodimeric IgG1 Fc, targeting CD16a on NK cells, and also used to connect the other two components of ABBV-303 A functional arm.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ABBV-303 Related Antibodies
SMILES

[ABBV-303]
Storage

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ABBV-303 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABBV-303ABBV303ABBV 303c-Met/HGFRADC AntibodyTriNKET?NK cellsnatural killer (NK) cell redirection therapysingle chain variable fragmentscFVFab armFc fragmentInhibitorinhibitorinhibit

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