2. Metabolic Enzyme/Protease Apoptosis
  3. Proteasome Apoptosis
  4. AK 295

AK 295 (CX 295) is a calpain inhibitor that inhibits apoptosis through a calpain-dependent pathway. AK 295 improves neurological function in a rat model of spinal cord injury (SCI). AK 295 can be used in the study of neurodegenerative diseases, such as bulbar amyotrophy, stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis.

For research use only. We do not sell to patients.

AK 295 Chemical Structure

AK 295 Chemical Structure

CAS No. : 160399-35-9

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Description

AK 295 (CX 295) is a calpain inhibitor that inhibits apoptosis through a calpain-dependent pathway. AK 295 improves neurological function in a rat model of spinal cord injury (SCI). AK 295 can be used in the study of neurodegenerative diseases, such as bulbar amyotrophy, stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis[1].

IC50 & Target

Calpain[1].
Molecular Weight

504.62

Formula

C26H40N4O6
CAS No.
SMILES

O=C(N[C@@H](CC(C)C)C(NC(C(C(NCCCN1CCOCC1)=O)=O)CC)=O)OCC2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AK 295 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AK 295160399-35-9CX 295AK295AK-295CX295CX-295ProteasomeApoptosisneurodegenerative diseasesapoptosisbulbar amyotrophystrokeAlzheimer's diseaseParkinson's diseasemultiple sclerosisInhibitorinhibitorinhibit

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