Aminooxy-PEG3-propargyl

Name: Aminooxy-PEG3-propargyl
Brand: MedChemExpress
SKU: HY-140057
Rating: 4.5 (1 reviews)

Cat. No.: HY-140057 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Aminooxy-PEG3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Aminooxy-PEG3-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Aminooxy-PEG3-propargyl Chemical Structure

CAS No. : 1807537-27-4

Size	Price	Stock	Quantity
5 mg	USD 45	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Aminooxy-PEG3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. Aminooxy-PEG3-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target^[1]

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

203.24

Formula

C₉H₁₇NO₄

CAS No.

1807537-27-4

Appearance

Liquid

Color

Colorless to light yellow

SMILES

NOCCOCCOCCOCC#C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 250 mg/mL (1230.07 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.9203 mL	24.6015 mL	49.2029 mL
5 mM	0.9841 mL	4.9203 mL	9.8406 mL
10 mM	0.4920 mL	2.4601 mL	4.9203 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (266 KB) SDS (0 KB)

COA (240 KB) HNMR (266 KB) MS (71 KB)

Handling Instructions (2659 KB)

References

[1]. Christopher Semko, et al. Rapamycin analogs as mtor inhibitors. WO2018204416A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.9203 mL	24.6015 mL	49.2029 mL	123.0073 mL
	5 mM	0.9841 mL	4.9203 mL	9.8406 mL	24.6015 mL
	10 mM	0.4920 mL	2.4601 mL	4.9203 mL	12.3007 mL
	15 mM	0.3280 mL	1.6401 mL	3.2802 mL	8.2005 mL
	20 mM	0.2460 mL	1.2301 mL	2.4601 mL	6.1504 mL
	25 mM	0.1968 mL	0.9841 mL	1.9681 mL	4.9203 mL
	30 mM	0.1640 mL	0.8200 mL	1.6401 mL	4.1002 mL
	40 mM	0.1230 mL	0.6150 mL	1.2301 mL	3.0752 mL
	50 mM	0.0984 mL	0.4920 mL	0.9841 mL	2.4601 mL
	60 mM	0.0820 mL	0.4100 mL	0.8200 mL	2.0501 mL
	80 mM	0.0615 mL	0.3075 mL	0.6150 mL	1.5376 mL
	100 mM	0.0492 mL	0.2460 mL	0.4920 mL	1.2301 mL