2. Immunology/Inflammation
  3. COX
  4. Anti-inflammatory agent 56

Anti-inflammatory agent 56 (Compound 9) is a selective COX-2 inhibitor (IC50: 0.54 μM). Anti-inflammatory agent 56 has anti-oxidant and anti-inflammatory effects. Anti-inflammatory agent 56 inhibits oxidative stress induced cell death. Anti-inflammatory agent 56 inhibits oxidative stress and neuroinflammation by inhibiting Keap1, COX-2 and iNOS. Anti-inflammatory agent 56 has low acute toxicity in mice (LD50: 1000 mg/kg).

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Anti-inflammatory agent 56 Chemical Structure

Anti-inflammatory agent 56 Chemical Structure

CAS No. : 2413127-32-7

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Description

Anti-inflammatory agent 56 (Compound 9) is a selective COX-2 inhibitor (IC50: 0.54 μM). Anti-inflammatory agent 56 has anti-oxidant and anti-inflammatory effects. Anti-inflammatory agent 56 inhibits oxidative stress induced cell death. Anti-inflammatory agent 56 inhibits oxidative stress and neuroinflammation by inhibiting Keap1, COX-2 and iNOS. Anti-inflammatory agent 56 has low acute toxicity in mice (LD50: 1000 mg/kg)[1].

IC50 & Target

COX-2

 

Molecular Weight

476.43

Formula

C21H15F3N4O4S
CAS No.
SMILES

O=S(N)(C1=CC=C(N2N=C(C3=C(O)C=C(C(F)(F)F)C=C3)N=C2C4=C(O)C=CC=C4)C=C1)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-inflammatory agent 56 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 562413127-32-7COXCyclooxygenaseanti-inflammatoryMCAO modelAcute ischemic strokeLPSInhibitorinhibitorinhibit

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