Anti-MRSA agent 11 

Anti-MRSA agent 11 suppresses fluoroquinolone-sensitive strain USA500 and -resistant MRSA isolate Mu50 (MIC =0.39 μg/mL). Anti-MRSA agent 11 displayes favorable in vivo half-life and safety profiles^[1].

Anti-MRSA agent 11 (100 μM; 24 h) is devoid of cytotoxicity in both A549 and HEK-293 cells. Anti-MRSA agent 11 highly selectives toxicity toward bacterial cells^[1].
Anti-MRSA agent 11 (0.25 μg/ml; 15 generation) has long-lasting antibacterial activity for MRSA strain ATCC33591^[1].
Anti-MRSA agent 11 can pass through the cell membrane of bacteria, especially the outer membrane of Gram-negative bacteria, and enter the interior of bacteria to play a role^[1].
Anti-MRSA agent 11 inhibits topoisomerase IV of bacteria, thereby interfering with the process of genetic material transfer of bacteria^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-MRSA agent 11 (0,400, 1000 and 2000 mg/kg, ig; everyday for 8 days) does not affect the body weight and food intake of the mice^[1].

Pharmacokinetic Analysis in male SD rats^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

448.42

C₂₄H₁₈F₂N₄O₃

3029704-83-1

O=C(C1=CN(C2CC2)C3=CC(NC4=NC=CC(CC5=CC=C(C=C5F)F)=N4)=CC=C3C1=O)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hongxue Dai,et al. Identification of CH2-linked quinolone-aminopyrimidine hybrids as potent.