2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Autophagy
  3. Ferroptosis Reactive Oxygen Species Autophagy
  4. Anticancer agent 193

Anticancer agent 193 (compound D3-3) is an inducer of ferritinophagy, eventually triggering ferroptosis. Anticancer agent 193 induces the production of lipid ROS, and significantly promoted colorectal cancer cells to release the ferrous ion in an autophagy-dependent manner.

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Anticancer agent 193 Chemical Structure

Anticancer agent 193 Chemical Structure

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Anticancer agent 193 Related Antibodies

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Description

Anticancer agent 193 (compound D3-3) is an inducer of ferritinophagy, eventually triggering ferroptosis. Anticancer agent 193 induces the production of lipid ROS, and significantly promoted colorectal cancer cells to release the ferrous ion in an autophagy-dependent manner[1].

In Vitro

Anticancer agent 193 (D3-3; 2.5-30 μM; 12-48 h) inhibits the proliferation of HCT-116 cells for 12, 24, and 48 h and the IC50 values are 15.06 μM, 11.18 μM, and 5.87 μM, respectively[1].
Anticancer agent 193 (D3-3; 5-20 μM; 12 h) considerably increases the autophagy marker protein LC3B-II/LC3B-I ratio. And it enhances FTH1 expression, a ferritin subunit[1].
Anticancer agent 193 (D3-3; 5-20 μM; 12 h) effectively promotes the accumulation of lipid ROS[1].
Anticancer agent 193 (D3-3) remarkably increases the level of ferrous iron in HCT-116 cells in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 193 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HCT-116 cells
Concentration: 2.5 μM, 5 μM, 7.5 μM,10 μM, 15 μM, 30 μM
Incubation Time: 12, 24, and 48 h
Result: Inhibited the proliferation of human colon cancer cells.

Western Blot Analysis[1]

Cell Line: HCT-116 cells
Concentration: 5 μM, 10 μM, 20 μM
Incubation Time: 12 h
Result: Induced ferritinophagy in HCT-116 cells through the LC3-NCOA4-FTH1 axis.
In Vivo

Anticancer agent 193 (D3-3; 30-60 mg/kg; i.p; daily; for 2 weeks) restraines tumor growth and promoted lipid peroxidation in the HCT-116 xenograft model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice injected with HCT-116 cells[1]
Dosage: 30 mg/kg or 60 mg/kg
Administration: i.p; daily; for 2 weeks
Result: Inhibited tumor growth in vivo.
Molecular Weight

615.20

Formula

C34H47ClN2O6
SMILES

O=C(CCCCCCCCCCCNC(C(Cl)=C)=O)OC1=C2C(C[C@H](N(C)CC3)[C@](C=C4OC)([H])[C@@]23CC4=O)=CC=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 193 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 193Anticancer agent193Anticancer agent-193FerroptosisReactive Oxygen SpeciesAutophagyferritinophagy inducersinomenine modificationcolorectal cancerlipid ROSInhibitorinhibitorinhibit

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