1. Anti-infection
  2. Bacterial
  3. Antimicrobial agent-5

Antimicrobial agent-5 is an potent antimicrobial agent, and displays excellent cell selectivity against Gram-negative bacteria and Gram-positive bacteria. Antimicrobial agent-5 blocks the interaction between LPS and CD14/TLR4 receptor, and shows anti-inflammatory activity against LPS-induced inflammation.

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Antimicrobial agent-5 Chemical Structure

Antimicrobial agent-5 Chemical Structure

CAS No. : 2978694-04-9

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Description

Antimicrobial agent-5 is an potent antimicrobial agent, and displays excellent cell selectivity against Gram-negative bacteria and Gram-positive bacteria. Antimicrobial agent-5 blocks the interaction between LPS and CD14/TLR4 receptor, and shows anti-inflammatory activity against LPS-induced inflammation[1].

In Vitro

Antimicrobial agent-5 (compound 9) (0.5-32 μg/mL, 16 h; 1-128 μg/mL; 24 h) shows potent biofilm inhibitory (IC50=2 μg/mL) and eradicating activities (IC50=16 μg/mL) against multidrug-resistant Pseudomonas aeruginosa (MDRPA)[1].
Antimicrobial agent-5 (5 μgmL, 20 μg/mL; 18 h) inhibits both the release and expression of nitric oxide (NO) and tumor necrosis factor-α (TNF-α) from LPS-stimulated (1 μg/mL) RAW 264.7 cells[1].
Antimicrobial agent-5 exhibits proteolytic resistance and salt/serum stability[1].
Antimicrobial agent-5 (0.5-256 μg/mL; 2 h) exhibits negligible side effects against sheep red blood cells (sRBCs) with hemolytic activity (the minimum hemolytic concentration, MHC) of >256 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: RAW264.7 cells
Concentration: 5 μg/mL, 20 μg/mL
Incubation Time: 18 hours
Result: Decreased TNF-α release at 20 μg/mL, with inhibition rate of 72.44%.
Results reduction in the LPS-stimulated production of NO, with inhibition rate of 31.51%.

Cell Viability Assay[1]

Cell Line: E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917], S. aureus [KCTC1621]
Concentration: 1-128 μg/mL
Incubation Time: 24 hours
Result: Inhibited Gram-negative bacteria and Gram-positive bacteria with IC50 of 6.1 μM (E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917], S. aureus [KCTC1621]), respectively.
Molecular Weight

656.83

Formula

C32H48N16

CAS No.
SMILES

NCCNC1=NC(NCCN)=NC(N(C(CN2C3=NC(NCCN)=NC(NCCN)=N3)CC4=CC=CC=C4)CC2CC5=CC=CC=C5)=N1

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Antimicrobial agent-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Antimicrobial agent-5
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HY-151399
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