2. Apoptosis
  3. Necroptosis
  4. Antitumor agent-145

Antitumor agent-145 (Compound Ir5) is a tumor inhibitor with remarkable fluorescence and mitochondrial targeting, which exerts anti-cancer effects by inducing necroptosis and activating the necroptosis-related immune response.

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Antitumor agent-145 Chemical Structure

Antitumor agent-145 Chemical Structure

CAS No. : 2983120-65-4

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Antitumor agent-145 Related Antibodies

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Description

Antitumor agent-145 (Compound Ir5) is a tumor inhibitor with remarkable fluorescence and mitochondrial targeting, which exerts anti-cancer effects by inducing necroptosis and activating the necroptosis-related immune response[1].

In Vitro

Antitumor agent-145 (Compound Ir5) (48 h) could effectively reduce the cell viability of BEL-7402/DDP cells with IC50 value of 0.49 μM and a resistance coefficient (RF) of 1.04. No obvious cytotoxicity Antitumor agent-145[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-145 Related Antibodies
In Vivo

Antitumor agent-145 (Compound Ir5) (1.5 or 3.0 mg/kg, intravenous injection, every other day for 21 days) significantly reduced tumor volume and inhibited tumor metastasis in BALB/c mice. Antitumor agent-145 does not cause significant liver and kidney dysfunction in mouse models[1].
Antitumor agent-145 (1.5 or 3.0 mg/kg, intravenous injection, every other day for 21 days) BEL-7402/DDP tumor xenograft models can significantly inhibit the growth and metastasis of CDDP resistant tumors without causing obvious tissue damage[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice
Dosage: NaCl, CDDP (3 mg/kg), Ir5 (1.5 mg/kg), and Ir5 (3 mg/kg)
Administration: every other day for 21 days
Result: The tumor volume in BALB/c mice was significantly reduced, and there was no significant difference in the weight of major organs.
Animal Model: BEL-7402/DDP tumor xenograft models
Dosage: 1.5 mg/kg or 3 mg/kg
Administration: every 2 days for 21 days
Result: The results revealed that Ir5 significantly decreases the tumor volume, with an inhibition rate of tumor growth (IRT) of 40.0% at a dose of 1.5 mg/kg and 58.1% at a dose of 3 mg/kg, compared to only 10.1% in the CDDP group. No obvious tissue injury.
Molecular Weight

873.06

Formula

C44H34IrN5OS
CAS No.
SMILES

OC1=C(C2=CC=CC=C2C=C1)/C=[N]3N=C(N(C)C)[S-][Ir+3]\345([N]6=C(C7=C(C=C6)C=CC=C7)C8=CC=CC=[C-]85)[N]9=C(C%10=C(C=C9)C=CC=C%10)C%11=CC=CC=[C-]%114
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Purity & Documentation
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Antitumor agent-145 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-1452983120-65-4Antitumor agent145Antitumor agent 145NecroptosisMitochondria-targetedcisplatin resistanceInhibitorinhibitorinhibit

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