2. Apoptosis
  3. Apoptosis
  4. Apoptosis inducer 17

Apoptosis inducer 17 is a Curcumin-Piperlongumine hybrid molecule that increases cell cycle arrest and apoptosis through activating JNK signaling pathway in lung cancer cells.

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Apoptosis inducer 17 Chemical Structure

Apoptosis inducer 17 Chemical Structure

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Apoptosis inducer 17 Related Antibodies

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Description

Apoptosis inducer 17 is a Curcumin-Piperlongumine hybrid molecule that increases cell cycle arrest and apoptosis through activating JNK signaling pathway in lung cancer cells[1].

In Vitro

Apoptosis inducer 17 (compound CP; 0.027-60 μM; 72 h) inhibits cell proliferation, with IC50 values of 0.021 μM, 0.027 μM, and 0.73 μM for H446, H1299, and SBC-2 cells, respectively[1].
Apoptosis inducer 17 (compound CP; 0.03-0.3 μM; 24 h) displays superior inhibition of colony formation. Apoptosis inducer 17 induces dose-dependent G2/M arrest in H446 and H1299 cells[1].
Apoptosis inducer 17 (compound CP; 0.03-0.3 μM; 24 h) induces apoptosis of H446 and H1299 cells is mediated by caspase activity. And also activates JNK signaling cascade[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 17 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: H446, H1299, and SBC-2 cells
Concentration: 60 μM, 20 μM, 6.67 μM, 2.22 μM, 0.74 μM, 0.25 μM, 0.082 μM, and 0.027 μM
Incubation Time: 72 h
Result: Effectively inhibited cell proliferation.

Cell Cycle Analysis[1]

Cell Line: H446, H1299 cells
Concentration: 0.03 μM, 0.1 μM, 0.3 μM
Incubation Time: 24 h
Result: Induced dose-dependent G2/M arrest.

Apoptosis Analysis[1]

Cell Line: H446, H1299 cells
Concentration: 0.03 μM, 0.1 μM, 0.3 μM
Incubation Time: 24 h
Result: Induced apoptosis of H446 and H1299 cells.

Western Blot Analysis[1]

Cell Line: H446, H1299 cells
Concentration: 0.03 μM, 0.1 μM, 0.3 μM
Incubation Time: 24 h
Result: Led to a dose-dependent increase in the phosphorylation of JNK, c-Jun and activating transcription factor-2 (ATF-2) in both H446 and H1299 cells.
In Vivo

Apoptosis inducer 17 (compound CP; 10 mg/kg; ip; twice a day; for 15 days) shows a significant reduction in H446 cell growth, without any significant changes in body weight[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (4-6 weeks old) injected with H446 cells[1]
Dosage: 10 mg/kg
Administration: ip; twice a day; for 15 days
Result: Prevented growth of lung cancer in xenograft tumors.
Molecular Weight

453.48

Formula

C25H27NO7
SMILES

O=C1N(C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O)CCC/C1=C\C3=CC=C(O)C(OC)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Apoptosis inducer 17 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 17Apoptosis inducer17Apoptosis inducer-17ApoptosisApoptosis InducerJNKCurcuminPiperlonguminecell cycle arrestanticancerInhibitorinhibitorinhibit

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