12S rRNA N4-methylcytidine

Definition:

N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA. Involved in the stabilization of 12S rRNA folding, therefore facilitating the assembly of the mitochondrial small ribosomal subunits.

References:

[1]. Hao Chen, et al. The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for mitochondrial function. J Biol Chem. 2020 Jun 19;295(25):8505-8513. [Content Brief]

[2]. Lindsey Van Haute, et al. METTL15 introduces N4-methylcytidine into human mitochondrial 12S rRNA and is required for mitoribosome biogenesis. Nucleic Acids Res. 2019 Nov 4;47(19):10267-10281. [Content Brief]

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