5'-3' exoribonuclease 2

Definition:

Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites.

References:

[1]. Natalia Gromak, et al. Pause sites promote transcriptional termination of mammalian RNA polymerase II. Mol Cell Biol. 2006 May;26(10):3986-96. [Content Brief]

[2]. Steven West, et al. Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites. Nature. 2004 Nov 25;432(7016):522-5. [Content Brief]

[3]. Konstantina Skourti-Stathaki, et al. Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination. Mol Cell. 2011 Jun 24;42(6):794-805. [Content Brief]

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