Centrosomal protein of 295 kDa

Definition:

Centriole-enriched microtubule-binding protein involved in centriole biogenesis. Essential for the generation of the distal portion of new-born centrioles in a CENPJ- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure. Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles. Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement. Binds to and stabilizes centriolar microtubule.

References:

[1]. Ching-Wen Chang, et al. CEP295 interacts with microtubules and is required for centriole elongation. J Cell Sci. 2016 Jul 1;129(13):2501-13. [Content Brief]

[2]. Enrico S Atorino, et al. CEP44 ensures the formation of bona fide centriole wall, a requirement for the centriole-to-centrosome conversion. Nat Commun. 2020 Feb 14;11(1):903. [Content Brief]

[3]. Denisse Izquierdo, et al. Stabilization of cartwheel-less centrioles for duplication requires CEP295-mediated centriole-to-centrosome conversion. Cell Rep. 2014 Aug 21;8(4):957-65. [Content Brief]

[4]. Victoria J Knorz, et al. Centriolar association of ALMS1 and likely centrosomal functions of the ALMS motif-containing proteins C10orf90 and KIAA1731. Mol Biol Cell. 2010 Nov 1;21(21):3617-29. [Content Brief]

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