Jamestown Canyon encephalitis

Definition:

Jamestown Canyon encephalitis is a rare infectious disease characterized by acute fever, meningitis, or meningoencephalitis. It is caused by Jamestown Canyon virus (JCV), a mosquito-borne orthobunyavirus in the California serogroup in the order Bunyavirales of -ssRNA viruses. JCV was first isolated in 1961 from mosquitoes in Jamestown, Colorado. Since then, the virus has been isolated from various mosquito species. JCV neutralizing antibodies have been found in various mammals throughout mainland North America, and identified in humans.

References:

[1]. Christine M Gill, et al. Five Emerging Neuroinvasive Arboviral Diseases: Cache Valley, Eastern Equine Encephalitis, Jamestown Canyon, Powassan, and Usutu. Semin Neurol. 2019 Aug;39(4):419-427. [Content Brief]

[2]. Daniel M Pastula, et al. Jamestown Canyon Virus Disease in the United States-2000-2013. Am J Trop Med Hyg. 2015 Aug;93(2):384-9. [Content Brief]

[3]. Martin Savard, et al. Jamestown Canyon encephalitis with NORSE and electrographic response to ribavirin: a case report. Epilepsia Open. 2018 Apr 17;3(2):286-289. [Content Brief]

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