P2X purinoceptor 7

Definition:

Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells.

References:

[1]. A Dessa Sadovnick, et al. Purinergic receptors P2RX4 and P2RX7 in familial multiple sclerosis. Hum Mutat. 2017 Jun;38(6):736-744. [Content Brief]

[2]. Ben J Gu, et al. P2X(7) is a scavenger receptor for apoptotic cells in the absence of its ligand, extracellular ATP. J Immunol. 2011 Sep 1;187(5):2365-75. [Content Brief]

[3]. Ben J Gu, et al. A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration. FASEB J. 2013 Apr;27(4):1479-87. [Content Brief]

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