Palmitoleoyl-protein carboxylesterase NOTUM

Definition:

Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.

References:

[1]. Satoshi Kakugawa, et al. Notum deacylates Wnt proteins to suppress signalling activity. Nature. 2015 Mar 12;519(7542):187-192. [Content Brief]

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