Phospholipid-transporting ATPase VA

Definition:

Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking. Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix. Has low flippase activity toward glucosylceramide (GlcCer).

References:

[1]. Naoto Takada, et al. Phospholipid-flipping activity of P4-ATPase drives membrane curvature. EMBO J. 2018 May 2;37(9):e97705. [Content Brief]

[2]. Bartholomew P Roland, et al. Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs. J Biol Chem. 2019 Feb 8;294(6):1794-1806. [Content Brief]

[3]. Tomoki Naito, et al. Phospholipid Flippase ATP10A Translocates Phosphatidylcholine and Is Involved in Plasma Membrane Dynamics. J Biol Chem. 2015 Jun 12;290(24):15004-17. [Content Brief]

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