Phytanoyl-CoA dioxygenase domain-containing protein 1

Definition:

2-oxoglutarate(2OG)-dependent dioxygenase that catalyzes the conversion of 2-oxoglutarate to succinate and CO(2) in an iron-dependent manner. However, does not couple 2OG turnover to the hydroxylation of acyl-coenzyme A derivatives, implying that it is not directly involved in phytanoyl coenzyme-A metabolism. Does not show detectable activity towards fatty acid CoA thioesters.; [Isoform 2]: Isoform 2 probably lacks enzyme activity.; [Isoform 3]: Isoform 3 probably lacks enzyme activity.

References:

[1]. Zhihong Zhang, et al. Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase. Biochem Biophys Res Commun. 2011 May 20;408(4):553-8. [Content Brief]

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