PiggyBac transposable element-derived protein 5

Definition:

Transposase that mediates sequence-specific genomic rearrangements. Can induce genomic rearrangements that inactivate the HPRT1 gene.

References:

[1]. Anton G Henssen, et al. Genomic DNA transposition induced by human PGBD5. Elife. 2015 Sep 25;4:e10565. [Content Brief]

[2]. Anton G Henssen, et al. Forward genetic screen of human transposase genomic rearrangements. BMC Genomics. 2016 Aug 4;17:548. [Content Brief]

[3]. Anton G Henssen, et al. PGBD5 promotes site-specific oncogenic mutations in human tumors. Nat Genet. 2017 Jul;49(7):1005-1014. [Content Brief]

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