Pirin

Definition:

Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).

References:

[1]. Fange Liu, et al. Pirin is an iron-dependent redox regulator of NF-κB. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9722-7. [Content Brief]

[2]. Isao Miyazaki, et al. A small-molecule inhibitor shows that pirin regulates migration of melanoma cells. Nat Chem Biol. 2010 Sep;6(9):667-73. [Content Brief]

[3]. Melanie Adams, et al. Structural and biochemical analysis reveal pirins to possess quercetinase activity. J Biol Chem. 2005 Aug 5;280(31):28675-82. [Content Brief]

[4]. S Licciulli, et al. Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation. Leukemia. 2010 Feb;24(2):429-37. [Content Brief]

[5]. Brian D Gelbman, et al. Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis. Respir Res. 2007 Feb 8;8(1):10. [Content Brief]

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