Polyamine-transporting ATPase 13A3

Definition:

ATP-driven pump involved in endocytosis-dependent polyamine transport. Uses ATP as an energy source to transfer polyamine precursor putrescine from the endosomal compartment to the cytosol.

References:

[1]. Norin Nabil Hamouda, et al. ATP13A3 is a major component of the enigmatic mammalian polyamine transport system. J Biol Chem. 2021 Jan-Jun;296:100182. [Content Brief]

[2]. Meenu Madan, et al. ATP13A3 and caveolin-1 as potential biomarkers for difluoromethylornithine-based therapies in pancreatic cancers. Am J Cancer Res. 2016 Jun 1;6(6):1231-52. [Content Brief]

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