Potassium voltage-gated channel subfamily H member 2

Definition:

Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr).; [Isoform A-USO]: Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.; [Isoform B-USO]: Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.

References:

[1]. Kai Li, et al. Tetrameric Assembly of K+ Channels Requires ER-Located Chaperone Proteins. Mol Cell. 2017 Jan 5;65(1):52-65. [Content Brief]

[2]. Yudi Kang, et al. Regulation of the human ether-a-go-go-related gene (hERG) potassium channel by Nedd4 family interacting proteins (Ndfips). Biochem J. 2015 Nov 15;472(1):71-82. [Content Brief]

[3]. Leonardo Guasti, et al. Identification of a posttranslational mechanism for the regulation of hERG1 K+ channel expression and hERG1 current density in tumor cells. Mol Cell Biol. 2008 Aug;28(16):5043-60. [Content Brief]

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