Pre-mRNA-processing-splicing factor 8

Definition:

Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.

References:

[1]. Richard J Grainger, et al. Prp8 protein: at the heart of the spliceosome. RNA. 2005 May;11(5):533-57. [Content Brief]

[2]. Xiaofeng Zhang, et al. An Atomic Structure of the Human Spliceosome. Cell. 2017 May 18;169(5):918-929.e14. [Content Brief]

[3]. Xiechao Zhan, et al. Structure of a human catalytic step I spliceosome. Science. 2018 Feb 2;359(6375):537-545. [Content Brief]

[4]. H R Luo, et al. The human Prp8 protein is a component of both U2- and U12-dependent spliceosomes. RNA. 1999 Jul;5(7):893-908. [Content Brief]

[5]. Xiaofeng Zhang, et al. Structure of the human activated spliceosome in three conformational states. Cell Res. 2018 Mar;28(3):307-322. [Content Brief]

[6]. Karl Bertram, et al. Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature. 2017 Feb 16;542(7641):318-323. [Content Brief]

[7]. Karl Bertram, et al. Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. Cell. 2017 Aug 10;170(4):701-713.e11. [Content Brief]

[8]. Xiechao Zhan, et al. Structures of the human pre-catalytic spliceosome and its precursor spliceosome. Cell Res. 2018 Dec;28(12):1129-1140. [Content Brief]

[9]. David Haselbach, et al. Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex. Cell. 2018 Jan 25;172(3):454-464.e11. [Content Brief]

[10]. Xiaofeng Zhang, et al. Structures of the human spliceosomes before and after release of the ligated exon. Cell Res. 2019 Apr;29(4):274-285. [Content Brief]

[11]. Claudia Schneider, et al. Human U4/U6.U5 and U4atac/U6atac.U5 tri-snRNPs exhibit similar protein compositions. Mol Cell Biol. 2002 May;22(10):3219-29. [Content Brief]

[12]. Sebastian M Fica, et al. A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation. Science. 2019 Feb 15;363(6428):710-714. [Content Brief]

[13]. Eun Joo Song, et al. The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. Genes Dev. 2010 Jul 1;24(13):1434-47. [Content Brief]

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