Prefrontal cortical (PFC)

Definition:

The prefrontal cortex (PFC) is the region of the cerebral cortex which covers the anterior portion of the frontal lobe. It is situated rostral to Brodmann area 6, including that on the orbital surface, and is particularly well-developed in primates, especially man. The PFC can be divided into the medial prefrontal cortex (mPFC), the orbitofrontal cortex, the ventrolateral PFC, the dorsolateral PFC (DLPFC), and the caudal PFC. PFC receives input from all other cortical regions and functions to plan and direct motor, cognitive, affective, and social behavior across time.

References:

[1]. Bryan Kolb, et al. Experience and the developing prefrontal cortex. Proc Natl Acad Sci U S A. 2012 Oct 16;109 Suppl 2(Suppl 2):17186-93. [Content Brief]

[2]. Wei-Yi Ong, et al. Role of the Prefrontal Cortex in Pain Processing. Mol Neurobiol. 2019 Feb;56(2):1137-1166. [Content Brief]

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