Probable proton-coupled zinc antiporter SLC30A3

Definition:

Probable proton-coupled zinc ion antiporter mediating the import of zinc from cytoplasm into synaptic vesicles and participating to cellular zinc ion homeostasis in the brain.

References:

[1]. Michael S Hildebrand, et al. Loss of synaptic Zn2+ transporter function increases risk of febrile seizures. Sci Rep. 2015 Dec 9;5:17816. [Content Brief]

[2]. Gloria Salazar, et al. SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity. PLoS One. 2009 Jun 12;4(6):e5896. [Content Brief]

[3]. Juan M Falcón-Pérez, et al. Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. Exp Cell Res. 2007 Apr 15;313(7):1473-83. [Content Brief]

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