Proline-rich protein 13

Definition:

Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis.

References:

[1]. Chih-Jian Lih, et al. Txr1: a transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes. Genes Dev. 2006 Aug 1;20(15):2082-95. [Content Brief]

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