Protein argonaute-1

Definition:

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).

References:

[1]. Gunter Meister, et al. Identification of novel argonaute-associated proteins. Curr Biol. 2005 Dec 6;15(23):2149-55. [Content Brief]

[2]. Bethany A Janowski, et al. Involvement of AGO1 and AGO2 in mammalian transcriptional silencing. Nat Struct Mol Biol. 2006 Sep;13(9):787-92. [Content Brief]

[3]. Ligang Wu, et al. Importance of translation and nonnucleolytic ago proteins for on-target RNA interference. Curr Biol. 2008 Sep 9;18(17):1327-32. [Content Brief]

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