Protein CBFA2T1

Definition:

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12. Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal.

References:

[1]. J Nathan Davis, et al. The ETO (MTG8) gene family. Gene. 2003 Jan 16;303:1-10. [Content Brief]

[2]. Stefano Rossetti, et al. The MTG proteins: chromatin repression players with a passion for networking. Genomics. 2004 Jul;84(1):1-9. [Content Brief]

[3]. Caitlyn W Barrett, et al. Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. PLoS One. 2012;7(12):e51205. [Content Brief]

[4]. Xiao-Jian Sun, et al. A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis. Nature. 2013 Aug 1;500(7460):93-7. [Content Brief]

[5]. A M Melnick, et al. The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein. Mol Cell Biol. 2000 Mar;20(6):2075-86. [Content Brief]

[6]. J D Wood, et al. Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription. J Cell Biol. 2000 Sep 4;150(5):939-48. [Content Brief]

[7]. Michael J Plevin, et al. The acute myeloid leukemia fusion protein AML1-ETO targets E proteins via a paired amphipathic helix-like TBP-associated factor homology domain. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10242-10247. [Content Brief]

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