Protein chibby homolog 1

Definition:

Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.

References:

[1]. Ken-Ichi Takemaru, et al. Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway. Nature. 2003 Apr 24;422(6934):905-9. [Content Brief]

[2]. Sumi Hidaka, et al. PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2. J Biol Chem. 2004 Aug 13;279(33):35009-16. [Content Brief]

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