Protrudin

Definition:

Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (By similarity). Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein and facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner.

References:

[1]. Michiko Shirane, et al. Protrudin induces neurite formation by directional membrane trafficking. Science. 2006 Nov 3;314(5800):818-21. [Content Brief]

[2]. Jaerak Chang, et al. Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14954-9. [Content Brief]

[3]. Fumiko Matsuzaki, et al. Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation. Mol Biol Cell. 2011 Dec;22(23):4602-20. [Content Brief]

[4]. Shotaro Saita, et al. Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein. J Biol Chem. 2009 May 15;284(20):13766-13777. [Content Brief]

[5]. Yutaka Hashimoto, et al. Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia. J Biol Chem. 2014 May 9;289(19):12946-61. [Content Brief]

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