Pulmonary surfactant-associated protein A1

Definition:

In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages (By similarity).; (Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule. Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages.; (Microbial infection) Binds M.pneumoniae CARDS toxin, serves as one receptor for this pathogen. When SFTPA1 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen.

References:

[1]. Zvjezdana Sever-Chroneos, et al. Surfactant protein A (SP-A)-mediated clearance of Staphylococcus aureus involves binding of SP-A to the staphylococcal adhesin eap and the macrophage receptors SP-A receptor 210 and scavenger receptor class A. J Biol Chem. 2011 Feb 11;286(6):4854-70. [Content Brief]

[2]. Maria V Carroll, et al. Identification of four novel DC-SIGN ligands on Mycobacterium bovis BCG. Protein Cell. 2010 Sep;1(9):859-70. [Content Brief]

[3]. T R Kannan, et al. Identification and characterization of human surfactant protein A binding protein of Mycoplasma pneumoniae. Infect Immun. 2005 May;73(5):2828-34. [Content Brief]

[4]. Sudha R Somarajan, et al. Annexin A2 mediates Mycoplasma pneumoniae community-acquired respiratory distress syndrome toxin binding to eukaryotic cells. mBio. 2014 Aug 19;5(4):e01497-14. [Content Brief]

[5]. Aude Ragas, et al. The Mycobacterium tuberculosis cell-surface glycoprotein apa as a potential adhesin to colonize target cells via the innate immune system pulmonary C-type lectin surfactant protein A. J Biol Chem. 2007 Feb 23;282(8):5133-42. [Content Brief]

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