Putative cytochrome P450 2D7

Definition:

May be responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It may be involved in the metabolism of codeine to morphine. However, another study could not confirm it.

References:

[1]. Wei-Yan Zhang, et al. Expression and functional analysis of CYP2D6.24, CYP2D6.26, CYP2D6.27, and CYP2D7 isozymes. Drug Metab Dispos. 2009 Jan;37(1):1-4. [Content Brief]

[2]. Harish V Pai, et al. A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine. J Biol Chem. 2004 Jun 25;279(26):27383-9. [Content Brief]

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