Pyogenic bacterial infections, recurrent, due to MYD88 deficiency

Definition:

Autosomal recessive MyD88 deficiency predisposes affected patients to recurrent pyogenic bacterial infections, including invasive pneumococcal disease. The patients are resistant to other microbes.

References:

[1]. Aziz Bousfiha, et al. Primary immunodeficiencies of protective immunity to primary infections. Clin Immunol. 2010 May;135(2):204-9. [Content Brief]

[2]. Capucine Picard, et al. Infectious diseases in patients with IRAK-4, MyD88, NEMO, or IκBα deficiency. Clin Microbiol Rev. 2011 Jul;24(3):490-7. [Content Brief]

[3]. Horst von Bernuth, et al. Pyogenic bacterial infections in humans with MyD88 deficiency. Science. 2008 Aug 1;321(5889):691-6. [Content Brief]

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